Annals of Hematology

, Volume 87, Issue 10, pp 837–845 | Cite as

Multivariate analysis of factors influencing oral mucositis in allogeneic hematopoietic stem cell transplantation

  • Yumiko Ohbayashi
  • Osamu Imataki
  • Hiroaki Ohnishi
  • Akinori Iwasaki
  • Takaaki Ogawa
  • Noriko Inagaki
  • Hiroe Shigeta
  • Yukiko Ohue
  • Taizo Tasaka
  • Akira Kitanaka
  • Yoshitsugu Kubota
  • Terukazu Tanaka
  • Toshihiko Ishida
  • Minoru Miyake
Original Article


Little information is available regarding the effect of oral intervention on the outcome of hematopoietic stem cell transplantation (HSCT). We retrospectively analyzed the incidence of oral mucositis after allogeneic HSCT with or without oral intervention among 96 consecutive patients in our hospital between January 1988 and March 2006. We combined two oral intervention strategies: cryotherapy and oral health care. The former was applied beginning in 2003 for patients being treated with melphalan, and the latter, which was the study’s main strategy, was applied to all HSCT recipients beginning in 2004. Oral mucositis was evaluated according to NCI CTCAE v3.0. The incidence of oral mucositis was 30.9% (17/55) in reduced-intensity stem cell transplantation (RIST), which was significantly lower than the 90.2% (37/41) in conventional stem cell transplantation (CST; P < 0.001). Among these 96 patients, severe oral mucositis was observed in 19 (46.3%) CST cases and in 6 (10.9%) RIST cases (P < 0.001). The occurrence of oral mucositis apparently decreased after oral health care instructions were given. Multiple logistic analysis revealed that the conditioning regimen and oral health care were independent risk factors for the incidence of oral mucositis. The cryotherapy did not exert enough potency to prevent oral mucositis in patients who had undergone CST or RIST. We concluded that oral health care improved tissue damage due to an overall upgrade in oral hygiene during chemotherapy.


Oral mucositis Allogeneic hematopoietic stem cell transplantation (HSCT) Multivariate analysis Risk factors 


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Copyright information

© Springer-Verlag 2008

Authors and Affiliations

  • Yumiko Ohbayashi
    • 1
  • Osamu Imataki
    • 2
  • Hiroaki Ohnishi
    • 2
  • Akinori Iwasaki
    • 1
  • Takaaki Ogawa
    • 1
  • Noriko Inagaki
    • 3
  • Hiroe Shigeta
    • 3
  • Yukiko Ohue
    • 3
  • Taizo Tasaka
    • 4
  • Akira Kitanaka
    • 5
  • Yoshitsugu Kubota
    • 6
  • Terukazu Tanaka
    • 7
  • Toshihiko Ishida
    • 8
  • Minoru Miyake
    • 1
  1. 1.Department of Oral and Maxillofacial Surgery, Faculty of MedicineKagawa UniversityKagawaJapan
  2. 2.Division of Hematology, Department of Internal Medicine, Faculty of MedicineKagawa UniversityKagawaJapan
  3. 3.Hematology & Stem Cell Transplantation Ward, Faculty of MedicineKagawa UniversityKagawaJapan
  4. 4.Department of Clinical Pathology and Laboratory MedicineKawasaki Medical SchoolOkayamaJapan
  5. 5.Department of Laboratory Medicine, Faculty of MedicineKagawa UniversityKagawaJapan
  6. 6.Department of Transfusion Medicine, Faculty of MedicineKagawa UniversityKagawaJapan
  7. 7.Environmental Health Sciences, Faculty of MedicineKagawa UniversityKagawaJapan
  8. 8.Department of Internal Medicine, Faculty of MedicineKagawa UniversityKagawaJapan

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