Annals of Hematology

, Volume 86, Issue 11, pp 831–835

The relationship between iron overload and clinical characteristics in a Spanish cohort of 100 C282Y homozygous hemochromatosis patients

  • Albert Altes
  • Angels Ruiz
  • Clara Martinez
  • Anna Esteve
  • Maria Dolores Vela
  • Angel Francisco Remacha
  • Pilar Sarda
  • Vanessa Bach
  • Montserrat Baiget
Original Article

Abstract

We studied the relationship between iron removed by venesection, sex, age, and clinical characteristics in a group of 100 Spanish probands with hereditary hemochromatosis (HH), all C282Y homozygous in the HFE gene. Iron overload was higher in men than in women (P < 0.0001) and increased with age (P = 0.02). Forty-four patients presented with liver disease (28 had fibrosis–cirrhosis of the liver), 24 with diabetes, 18 with arthropathy, and 13/73 men with impotence. No clinical consequences of hemochromatosis were observed in 43 patients. The number of clinical complications was higher in men (P = 0.01) and increased with age (P = 0.006) and with the amount of iron removed (P < 0.0001). The amount of iron removed was significantly higher by univariate analysis in patients with liver disease (P < 0.0001), diabetes (P = 0.007), arthropathy (P = 0.006), and impotence (P = 0.003) than in patients without these complications. In the multivariant analysis, only liver disease maintained a significant relationship with the amount of iron removed (P < 0.0001). Diabetes and arthropathy were closely related with previous liver disease, and impotence appeared mainly in hemochromatosic men with diabetes and alcoholism.

Keywords

Hemochromatosis Liver cirrhosis Diabetes Arthropathy Impotence 

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Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  • Albert Altes
    • 1
    • 4
  • Angels Ruiz
    • 1
  • Clara Martinez
    • 1
  • Anna Esteve
    • 1
  • Maria Dolores Vela
    • 2
  • Angel Francisco Remacha
    • 3
  • Pilar Sarda
    • 3
  • Vanessa Bach
    • 3
  • Montserrat Baiget
    • 3
  1. 1.Hematology DepartmentHospital de l’Esperit Sant de Santa Coloma de GramenetBarcelonaSpain
  2. 2.Hematology DepartmentHospital de Blanes-CalellaBarcelonaSpain
  3. 3.Hematology and Genetics ServiceHospital de Sant PauBarcelonaSpain
  4. 4.Servei de laboratoryHospital de l’Esperit Sant de Santa Coloma de GramenetBarcelonaSpain

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