Annals of Hematology

, Volume 86, Issue 2, pp 127–132

Long-term follow-up of allogeneic HSCT for CML reveals significant improvement in the outcome over the last decade

  • Martin Weisser
  • Georg Ledderose
  • Hans Jochem Kolb
Original Article

Abstract

Allogeneic hematopoetic stem cell transplantation (HSCT) is still the only curative therapeutic option for chronic myelogenous leukemia (CML). To examine the development of allogeneic HSCT at our center over the past two decades (decade 1: 1984–1994; decade 2: 1995–2005), all CML patients transplanted in first chronic phase (n = 234) were analyzed with respect to patient characteristics, overall survival, transplant-related mortality (TRM), and relapse incidence. The median follow up time was 54 months (range 1–218). The incidence of acute graft vs host disease (GvHD) °II–IV and extensive chronic GvHD were not different between the two decades (p = 0.894 and p = 0.422, respectively). There was also no difference in the relapse incidence (23 vs 26%, p = 0.869). One-year TRM and overall survival were improved in the later decade (33 vs 18%, p = 0.011 and 62 vs 73% at 5 years, p = 0.063, respectively). The major reason for improved outcome in decade 2 was the improved management of acute GvHD and infections in the early phase after transplantation (p = 0.026). In conclusion, the past decade has seen significant improvement in the performance of allogeneic HSCT for CML.

Keywords

Chronic myelogenous leukemia Allogeneic transplantation 

Copyright information

© Springer-Verlag 2006

Authors and Affiliations

  • Martin Weisser
    • 1
  • Georg Ledderose
    • 1
  • Hans Jochem Kolb
    • 1
  1. 1.Clinical Cooperative Group for Haematopoetic Cell Transplantation, Department of Medicine IIIUniversity of Munich, Klinikum Grosshadern and GSF-National Research Center for Environment and HealthMunichGermany

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