Annals of Hematology

, Volume 85, Issue 10, pp 741–742 | Cite as

Relapse of acute promyelocytic leukemia presenting as granulocytic sarcoma in the hip

  • Neeraj Agarwal
  • Elizabeth M. Tepe
  • Archana Mishra
  • John H. Ward
Letter to the editor

Dear editor,

A 43-year-old male presented in January of 2006 with a 4-month history of progressive right hip pain and a 2-week history of easy bruising and fatigue. His history was notable for acute promyelocytic leukemia (APL), diagnosed in the June of 2003, for which he had been treated with induction chemotherapy consisting of idarubicin and all-trans retinoic acid (ATRA), and achieved a complete remission. Then he received two courses of consolidation therapy with idarubicin and was placed on maintenance therapy with ATRA for 15 days every 3 months for the next 2 years. The patient discontinued his maintenance therapy after only 6 months.

Examination was remarkable for multiple petechiae and markedly diminished range of motion of the right hip joint due to pain. Laboratory data were remarkable for hemoglobin 12 g/dl, hematocrit 31%, platelets 17,000×109/l, WBC 26.4×109/l, fibrinogen level 108 ng/ml, and d-dimer 3.3 mcg/ml. In the peripheral blood smear, 80% of white cells were...


Acute Myeloid Leukemia Acute Promyelocytic Leukemia Bone Marrow Aspirate Idarubicin Consolidation Chemotherapy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag 2006

Authors and Affiliations

  • Neeraj Agarwal
    • 1
    • 2
  • Elizabeth M. Tepe
    • 1
  • Archana Mishra
    • 3
  • John H. Ward
    • 1
  1. 1.Divisions of Hematology and Oncology, Department of Internal MedicineUniversity of Utah Hospitals and ClinicsSalt Lake CityUSA
  2. 2.Huntsman Cancer InstituteSalt Lake CityUSA
  3. 3.Department of PathologyUniversity of Utah Hospitals and ClinicsSalt Lake CityUSA

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