Annals of Hematology

, 85:514 | Cite as

A case-control study of myelodysplastic syndromes in Belgrade (Serbia Montenegro)

  • Tatjana Pekmezovic
  • Nada Suvajdzic Vukovic
  • Darija Kisic
  • Anita Grgurevic
  • Andrija Bogdanovic
  • Mirjana Gotic
  • Milena Bakrac
  • Nenad Brkic
Original Article


The objective of the study was to investigate factors related to the occurrence of myelodysplatic syndromes (MDS) in the population of Belgrade (Serbia Montenegro). The case-control study was conducted during the period 2000–2003. The study group consisted of 80 newly diagnosed MDS patients and 160 sex- and age-matched hospital controls with nonmalignant and noninfectious diseases. The disease categories in the control group were circulatory (51 patients, 32%), gastrointestinal (53 patients, 33%), and ophthalmological (56 patients, 35%) disorders. Conditional univariate and multivariate logistic regression analyses were applied. Multivariate analysis showed the following factors to be significantly related to MDS: exposure to chemicals (OR=10.8, 95%CI 3.2–36.2, p=0.0001), viral upper respiratory tract infections (twice a year or more, OR=5.8, 95%CI 2.5–13.6, p=0.0001), exposure to insecticides, pesticides and herbicides (OR=5.2, 95%CI 1.8–15.1, p=0.003), coffee (OR=5.1, 95%CI 1.9–13.7, p=0.001), and alcohol consumption (OR=2.2, 95%CI 1.1–4.6, p=0.033). The findings support the hypotheses that exposure to chemical agents, pesticides, insecticides, and herbicides, certain lifestyle factors (alcohol and coffee consumption), and frequent viral infections may be involved in the etiology of MDS, but these results should be confirmed by further investigations.


Myelodysplastic syndrome Risk factors Epidemiology Case-control study Belgrade 



This work was financially supported by the Ministry of Science and Environment Protection of Republic of Serbia through contract no. 1927/ 2002–2005. We would very much like to thank Dr H.D.E. Atkinson, Imperial College Medical School, Hammersmith Hospital, Du Cane Road, London, UK, for his critical review and assistance in the writing of this paper in English.


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Copyright information

© Springer-Verlag 2006

Authors and Affiliations

  • Tatjana Pekmezovic
    • 1
  • Nada Suvajdzic Vukovic
    • 2
  • Darija Kisic
    • 1
  • Anita Grgurevic
    • 1
  • Andrija Bogdanovic
    • 2
  • Mirjana Gotic
    • 2
  • Milena Bakrac
    • 2
  • Nenad Brkic
    • 2
  1. 1.Institute of Epidemiology, School of MedicineUniversity of BelgradeBelgrade 11000Serbia Montenegro
  2. 2.Clinical Centre of SerbiaInstitute of HematologyBelgrade 11000Serbia Montenegro

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