Annals of Hematology

, Volume 85, Issue 8, pp 530–534 | Cite as

Rituximab long-term maintenance therapy after autologous stem cell transplantation in patients with B-cell non-Hodgkin’s lymphoma

  • Frank Neumann
  • Stefani Harmsen
  • Simona Martin
  • Ralf Kronenwett
  • Mustafa Kondakci
  • Manuel Aivado
  • Ulrich Germing
  • Rainer Haas
  • Guido Kobbe
Original Article

Abstract

Treatment of B-cell non-Hodgkin’s lymphomas (NHL) with either Rituximab alone or in combination with cytotoxic chemotherapy has been effective without major side effects. Thus, Rituximab maintenance therapy after autologous peripheral blood stem cell transplantation (PBSCT) might represent an improvement in NHL therapy. We therefore retrospectively analyzed the efficacy and side effects of monthly long-term Rituximab maintenance therapy after PBSCT in 27 patients with NHL. In median 10 infusions of Rituximab were given after PBSCT in time intervals of 1 month. Molecular monitoring of t(14;18) was performed using nested as well as quantitative real time polymerase chain reaction (RT-PCR) based on the LightCycler technology. Side effects according to common toxicity criteria (CTC) > II did mainly affect the hematopoietic system. In total, 10 patients (37%) suffered form grade III–IV hematotoxicity. Except for two patients with cutaneous Varicella–Zoster infection no serious infectious complications (CTC grade III/IV) occurred. No patient died because of treatment-related causes. This adverse event data compared favorably to the published data. Three patients had t(14;18) nested RT-PCR positive results before Rituximab therapy and converted to negativity after Rituximab therapy. We conclude that a prolonged Rituximab maintenance therapy after PBSCT with monthly administration is reliable and safe.

Keywords

Non-Hodgkin’s lymphoma Rituximab maintenance Autologous stem cell transplantation 

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Copyright information

© Springer-Verlag 2006

Authors and Affiliations

  • Frank Neumann
    • 1
  • Stefani Harmsen
    • 1
  • Simona Martin
    • 2
  • Ralf Kronenwett
    • 1
  • Mustafa Kondakci
    • 1
  • Manuel Aivado
    • 1
  • Ulrich Germing
    • 1
  • Rainer Haas
    • 1
  • Guido Kobbe
    • 1
  1. 1.Department of Hematology, Oncology and Clinical ImmunologyHeinrich-Heine-UniversityDuesseldorfGermany
  2. 2.Institute for Transuranium ElementsEggenstein-LeopoldshafenGermany

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