Annals of Hematology

, Volume 85, Issue 6, pp 381–385 | Cite as

The impact of mode of delivery and gestational age on cord blood hematopoietic stem/progenitor cells

  • Helen Dimitriou
  • Chryssoula Perdikogianni
  • Eftichia Stiakaki
  • Pelagia Vorgia
  • Eleftheria Hatzidaki
  • Maria Kalmanti
Original Article

Abstract

Human cord blood has been successfully used as an alternative source of hematopoietic stem cells suitable for transplantation. The aim of this study was to assess the impact of gestational age and the mode of delivery on cord blood hematopoietic stem/progenitor cell characteristics. The mode of delivery does not seem to affect either the replating capacity of hematopoietic progenitors colony-forming unit-granulocyte-macrophage or the cord blood content in CD34+ cells. The higher percentage of CD34+ cells in cord blood from preterm deliveries compared to full-term ones indicates that hematopoietic progenitors from preterm cord blood may be suitable for transplantation. These findings should be taken into consideration when selection of cord blood units is required for potential use in transplantation.

Keywords

Cord blood Perinatal factors Progenitor cell yield Transplantation 

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Copyright information

© Springer-Verlag 2006

Authors and Affiliations

  • Helen Dimitriou
    • 1
    • 2
  • Chryssoula Perdikogianni
    • 1
    • 2
  • Eftichia Stiakaki
    • 1
    • 2
  • Pelagia Vorgia
    • 1
    • 2
  • Eleftheria Hatzidaki
    • 1
    • 2
  • Maria Kalmanti
    • 1
    • 2
  1. 1.Department of Paediatric Haematology/OncologyUniversity Hospital of HeraklionCreteGreece
  2. 2.Department of Paediatric Haematology/OncologyUniversity of Crete Medical SchoolCreteGreece

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