Annals of Hematology

, Volume 84, Issue 11, pp 742–747

Prospective randomized comparative observation of single- vs split-dose lenograstim to mobilize peripheral blood progenitor cells following chemotherapy in patients with multiple myeloma or non-Hodgkin’s lymphoma

  • Shin Kim
  • Hyo-Jung Kim
  • Jung Sun Park
  • Jungsin Lee
  • Hyun-Sook Chi
  • Chan Jeong Park
  • Jooryung Huh
  • Cheolwon Suh
Original Article

DOI: 10.1007/s00277-005-1103-8

Cite this article as:
Kim, S., Kim, HJ., Park, J.S. et al. Ann Hematol (2005) 84: 742. doi:10.1007/s00277-005-1103-8

Abstract

In patients with hematologic malignancies, granulocyte colony-stimulating factor (G-CSF) following chemotherapy is widely used to mobilize peripheral blood progenitor cells (PBPCs), but there have been no trials comparing schedules of G-CSF following chemotherapy. We conducted a prospective randomized comparative observation of the mobilization with a single dose (10 μg kg once a day) or split dose (5 μg kg twice a day) of lenograstim following chemotherapy in 25 multiple myeloma (MM) and 15 non-Hodgkin’s lymphoma (NHL) patients. Chemotherapy was cyclophosphamide 4 g/m2 for MM and ESHAP with or without Rituximab for NHL. The median number of harvested CD34+ cells was 19.4×106/kg and 15.8×106/kg in the single- and split-dose groups, respectively (p=0.47). Targeted collection of 5×106 CD34+ cells/kg was achieved in 18/20 patients in the single-dose group and in all 20 patients of the split-dose group (p=0.24), with the median number of sessions 1 and 2 in the single- and split-dose groups, respectively (p=0.13). We could not observe statistically significant differences between a single-dose and split-dose lenograstim following chemotherapy in enhancing the mobilization of PBPCs in MM or NHL patients.

Keywords

Mobilization G-CSF Autologous stem cell transplantation Non-Hodgkin’s lymphoma Multiple myeloma 

Copyright information

© Springer-Verlag 2005

Authors and Affiliations

  • Shin Kim
    • 1
  • Hyo-Jung Kim
    • 2
  • Jung Sun Park
    • 1
  • Jungsin Lee
    • 1
  • Hyun-Sook Chi
    • 3
  • Chan Jeong Park
    • 3
  • Jooryung Huh
    • 4
  • Cheolwon Suh
    • 1
  1. 1.Department of Internal Medicine, Asan Medical CenterUniversity of Ulsan College of MedicineSeoulSouth Korea
  2. 2.Department of Internal Medicine, College of MedicineHallym University Sacred Heart HospitalAnyangSouth Korea
  3. 3.Department of Diagnostic Laboratory Medicine, Asan Medical CenterUniversity of Ulsan College of MedicineSeoulSouth Korea
  4. 4.Department of Pathology, Asan Medical CenterUniversity of Ulsan College of MedicineSeoulSouth Korea

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