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Annals of Hematology

, Volume 84, Issue 12, pp 807–811 | Cite as

Randomized study of Helicobacter pylori eradication therapy and proton pump inhibitor monotherapy for idiopathic thrombocytopenic purpura

  • Yutaka TsutsumiEmail author
  • Hiroe Kanamori
  • Hiroaki Yamato
  • Nobuyuki Ehira
  • Takahito Kawamura
  • Shintaro Umehara
  • Akio Mori
  • Shinji Obara
  • Nobutaka Ogura
  • Junji Tanaka
  • Masahiro Asaka
  • Masahiro Imamura
  • Nobuo Masauzi
Original Article

Abstract

Helicobacter pylori (HP) eradication therapy is a useful treatment for idiopathic thrombocytopenic purpura (ITP). Some investigators have also reported the effects of proton pump inhibitor (PPI) monotherapy on ITP. We performed a randomized study of HP eradication therapy and PPI monotherapy on ITP. Four of nine patients achieved complete remission (CR), two of nine achieved partial remission (PR) in HP eradication therapy, three of eight achieved CR, and two of eight achieved PR in PPI monotherapy. No significant differences were observed in the CR + PR of these patients between HP eradication therapy and PPI monotherapy. As for cost comparisons, HP eradication therapy is cheaper than PPI monotherapy, but it is less effective.

Keywords

Proton pump inhibitor (PPI) Idiopathic thrombocytopenic purpura (ITP) Helicobacter pylori (HP) PA-IgG HP eradication therapy 

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Copyright information

© Springer-Verlag 2005

Authors and Affiliations

  • Yutaka Tsutsumi
    • 1
    Email author
  • Hiroe Kanamori
    • 1
  • Hiroaki Yamato
    • 1
  • Nobuyuki Ehira
    • 1
  • Takahito Kawamura
    • 1
  • Shintaro Umehara
    • 1
  • Akio Mori
    • 1
  • Shinji Obara
    • 1
  • Nobutaka Ogura
    • 1
  • Junji Tanaka
    • 2
  • Masahiro Asaka
    • 3
  • Masahiro Imamura
    • 2
  • Nobuo Masauzi
    • 1
  1. 1.Department of Internal MedicineHakodate Municipal HospitalHakodateJapan
  2. 2.Department of Hematology and OncologyHokkaido University Graduate School of MedicineSapporoJapan
  3. 3.Department of GastroenterologyHokkaido University Graduate School of MedicineSapporoJapan

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