Annals of Hematology

, Volume 85, Issue 3, pp 185–187 | Cite as

Use of rituximab as a salvage therapy for HIV-associated multicentric Castleman disease

  • Angela Casquero
  • Alicia Barroso
  • Manuel L. Fernández Guerrero
  • Miguel Górgolas
Letter to the Editor

Abstract

Several approved therapies for multicentric Castleman disease (MCD) cannot be uniformly applied due to intolerable side effects. There is also a high percentage of recurrence of this disease despite treatment. Rituximab may be effective in controlling MCD in a subset of patients. This paper includes a brief case report and an extensive review of previously published cases. We observed an aggravation of concomitant cutaneous Kaposi sarcoma, and hypothesize that rituximab could have exacerbated it.

Keywords

Rituximab Multicentric Castleman disease HIV Kaposi sarcoma 

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Copyright information

© Springer-Verlag 2005

Authors and Affiliations

  • Angela Casquero
    • 1
    • 3
  • Alicia Barroso
    • 2
  • Manuel L. Fernández Guerrero
    • 1
  • Miguel Górgolas
    • 1
  1. 1.Division of Infectious DiseasesFundación Jiménez Díaz-UTE, Universidad Autónoma de MadridMadridSpain
  2. 2.Pathology DepartmentFundación Jiménez Díaz-UTE, Universidad Autónoma de MadridMadridSpain
  3. 3. MadridSpain

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