Mesenteric venous thrombosis in a patient with congenital afibrinogenemia and diffuse peritonitis
- 53 Downloads
Congenital afibrinogenemia is a rare autosomal recessive hemorrhagic disorder, and thrombotic complications occurring spontaneously or after infusion of fibrinogen-containing preparations have been reported in afibrinogenemic patients . We report a case of mesenteric venous thrombosis due to fibrinogen replacement in a patient with congenital afibrinogenemia.
A 19-year-old male with congenital afibrinogenemia had previously undergone uneventful surgical procedures for splenic rupture, intracranial bleeding, and mandibular abscess (2002) with preoperative supplement of fibrinogen concentrate. He was urgently admitted to the Critical Care Medical Center and diagnosed with diffuse peritonitis in 2003. After prophylactic administration of ten units of fresh-frozen plasma (FFP), resection of the small intestine was performed. Numerous thromboses were detected in the mesenteric veins of the resected specimen. The color of the remaining small intestine darkened during wound closure and...
KeywordsFibrinogen Fibrinogen Level Activate Partial Thromboplastin Time Thrombocytosis Prothrombin Activation
The authors sincerely thank Prof. Osamu Matsuo and Dr. Shigeru Ueshima (Department of Physiology II, Kinki University School of Medicine, Japan) for thoughtful advice, and Mr. Shiori Masuda (Clinical Laboratory Department, Kinki University Hospital, Japan) and Dr. Chiaki Arai (Clinical Laboratory Department, Nippon Dental University Hospital, Japan) for the laboratory analysis.