Annals of Hematology

, Volume 83, Issue 7, pp 455–459

A male with angioimmunoblastic T-cell lymphoma and proliferative glomerulonephritis

  • Hadewijch De Samblanx
  • Gregor Verhoef
  • Pierre Zachée
  • Peter Vandenberghe
Case Report

DOI: 10.1007/s00277-003-0828-5

Cite this article as:
De Samblanx, H., Verhoef, G., Zachée, P. et al. Ann Hematol (2004) 83: 455. doi:10.1007/s00277-003-0828-5

Abstract

In this article we present the case report of a 67-year-old male with a nephrotic syndrome due to a proliferative glomerulonephritis, associated with an angioimmunoblastic T-cell lymphoma. Diagnosis was made on an axillary lymph node biopsy and showed expanded T-cell areas with multiple blood vessels, small mature lymphocytes, eosinophils, and plasma cells. A kidney biopsy was suggestive for a proliferative glomerulonephritis with intra- and extracapillary proliferation. Hypercellular glomeruli were seen, as well as multiple floride crescents. Interstitial edema and fibrosis were absent. Immunohistochemical reactions were negative; there was some mesangial reaction with IgM in the glomeruli. Treatment with high-dose corticosteroids was initiated, with clinical improvement, and was immediately followed by therapy with cyclophosphamide, hydroxydaunomycin, vincristine, and prednisone (CHOP), which induced complete remission with a follow-up of 1 year. To our knowledge, the association of angioimmunoblastic T-cell lymphoma and proliferative glomerulonephritis has only been described twice. It concerned elderly men who developed acute renal failure a couple of months after the diagnosis of an angioimmunoblastic T-cell lymphoma. In both, immunoglobulin-containing dense deposits within glomeruli were observed, which was not the case in our patient, where only some mesangial colorization of the IgM in the glomeruli was seen.

Keywords

Angioimmunoblastic T-cell lymphoma Proliferative glomerulonephritis 

Copyright information

© Springer-Verlag 2004

Authors and Affiliations

  • Hadewijch De Samblanx
    • 1
  • Gregor Verhoef
    • 1
  • Pierre Zachée
    • 2
  • Peter Vandenberghe
    • 1
    • 3
  1. 1.Hematology UnitUniversity Hospital LeuvenLeuvenBelgium
  2. 2.Stuyvenberg HospitalAntwerpBelgium
  3. 3.Center for Human GeneticsUniversity Hospital LeuvenLeuvenBelgium

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