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Annals of Hematology

, Volume 83, Issue 4, pp 232–236 | Cite as

Decreased frequency of HLA-B35 in patients with gastric MALT lymphoma

  • Peter ReimerEmail author
  • Wolfgang Fischbach
  • Maria-Elisabeth Goebeler
  • Michael Rupert Kraus
  • Shraga Goldmann
  • Carlheinz Müller
  • Martin Wilhelm
Original Article

Abstract

Persistent infection with Helicobacter pylori has been shown to be strongly associated with the development of low-grade gastric mucosa-associated lymphoid tissue (MALT) lymphoma. However, the prevalence of H. pylori infection exceeds the incidence of MALT lymphoma by far. This discrepancy might at least partially be explained on a genomic basis of the host. To evaluate the association between HLA type and MALT lymphoma, we investigated 46 patients with MALT lymphoma recruited in a prospective multicenter study from October 1998 to March 2001. Over 13,000 voluntary stem cell donors from over 40 German blood banks represented the control group. Exploratory statistical analysis using Fisher’s exact test showed significantly decreased frequency of HLA-B35 in the MALT lymphoma group compared to the control group. Our data suggest a negative association between HLA-B35 and MALT lymphoma; however, larger studies are necessary to confirm a protective role of this HLA antigen.

Keywords

MALT lymphoma HLA-B35 HLA antigen Gastric lymphoma Genetics 

Notes

Acknowledgements

The authors acknowledge Ulrich Stefenelli, Institute for Statistics, Domstr. 10, 97070 Wuerzburg, Germany for providing the statistical data.

References

  1. 1.
    Amoli MM, Thomson W, Hajeer AH, Calvino MC, Garcia-Porrua C, Ollier WE, Gonzalez-Gay MA (2002) HLA-B35 association with nephritis in Henoch-Schonlein purpura. J Rheumatol 29:948–949PubMedGoogle Scholar
  2. 2.
    d’Amore F, Christensen BE, Brincker H, Pedersen NT, Thorling K, Hastrup J, Pedersen M, Jensen MK, Johansen P, Andersen (1991) Clinicopathological features and prognostic factors in extranodal non-Hodgkin lymphomas. Danish LYFO Study Group. Eur J Cancer 27:1201–1208Google Scholar
  3. 3.
    d’Amore F, Brincker H, Gronbaek K, Thorling K, Pedersen M, Jensen MK, Andersen E, Pedersen NT, Mortensen LS (1994) Non-Hodgkin’s lymphoma of the gastrointestinal tract: a population-based analysis of incidence, geographic distribution, clinicopathologic presentation features, and prognosis. Danish Lymphoma Study Group. J Clin Oncol 12:1673–1684PubMedGoogle Scholar
  4. 4.
    Azuma T, Ito S, Sato F, Yamazaki Y, Miyaji H, Ito Y, Suto H, Kuriyama M, Kato T, Kohli Y (1998) The role of the HLA-DQA1 gene in resistance to atrophic gastritis and gastric adenocarcinoma induced by Helicobacter pylori infection. Cancer 82:1013–1018CrossRefPubMedGoogle Scholar
  5. 5.
    Bayerdorffer E, Neubauer A, Rudolph B, Thiede C, Lehn N, Eidt S, Stolte M (1995) Regression of primary gastric lymphoma of mucosa-associated lymphoid tissue type after cure of Helicobacter pylori infection. MALT Lymphoma Study Group. Lancet 345:1591–1594PubMedGoogle Scholar
  6. 6.
    Beales ILP, Davey N, Scunes D, Pusey C, Lechler R, Calam J (1994) HLA class II type and H. Pylori induced gastric atrophy (abstract). Gut 35:S45Google Scholar
  7. 7.
    Carbone PP, Kaplan HS, Musshoff K, Smithers DW, Tubiana M (1971) Report of the Committee on Hodgkin’s Disease Staging Classification. Cancer Res 31:1860–1861PubMedGoogle Scholar
  8. 8.
    Cuttner J, Skerrett D, Rosina O, Troy KM, Wallenstein S, Spivack M (1994) Increased incidence of HLA antigen B35 in patients with chronic lymphocytic leukemia. Leuk Res 18:565–567PubMedGoogle Scholar
  9. 9.
    O’Driscoll BR, Stevens FM, O’Gorman TA, Finnegan P, McWeeney JJ, Little MPG, Connelly CE, McCarthy CF (1982) HLA type of patients with coeliac disease and malignancy in the west of Ireland. Gut 23:662–665PubMedGoogle Scholar
  10. 10.
    Erlich H, Bugawan T, Begovich AB, Scharf S, Griffith R, Saiki R, Higuchi R, Walsch PS (1991) HLA-DR, DQ and DP typing using PCR amplification and immobilized probes. Eur J Immunogenetics 18:33–55Google Scholar
  11. 11.
    Fischbach W, Goebeler-Kolve M-E, Dragosics B, Greiner A, Stolte M (2003) Long-term outcome of patients with gastric marginal zone B-cell lymphoma of MALT following exclusive Helicobacter pylori eradication therapy: experience from a large prospective series. Gut, in pressGoogle Scholar
  12. 12.
    Harris NL, Jaffe ES, Stein H, Banks PM, Chan JK, Cleary ML, Delsol G, De Wolf-Peeters, Falini B, Gatter KC (1994) A revised European-American classification of lymphoid neoplasms: a proposal from the International Lymphoma Study Group. Blood 84:1361–1392PubMedGoogle Scholar
  13. 13.
    Harris NL, Jaffe ES, Diebold J, Flandrin G, Muller-Hermelink HK, Vardiman J, Lister TA, Bloomfield CD (1999) World Health Organization classification of neoplastic diseases of the hematopoietic and lymphoid tissues: report of the Clinical Advisory Committee meeting-Airlie House, Virginia, November 1997. J Clin Oncol 17:3835–3849PubMedGoogle Scholar
  14. 14.
    Hoon DS, Okamoto T, Wang HJ, Elashoff R, Nizze AJ, Foshag LJ, Gammon G, Morton DL (1998) Is the survival of melanoma patients receiving polyvalent melanoma cell vaccine linked to the human leukocyte antigen phenotype of patients? J Clin Oncol 16:1430–1437PubMedGoogle Scholar
  15. 15.
    Isaacson P, Wright DH (1984) Extranodal malignant lymphoma arising from mucosa-associated lymphoid tissue. Cancer 53:2515–2524PubMedGoogle Scholar
  16. 16.
    Itescu S, Mathur-Wagh U, Skovron ML, Brancato LJ, Marmor M, Zeleniuch-Jacquotte A, Winchester R (1992) HLA-B35 is associated with accelerated progression to AIDS. J Acquir Immune Defic Syndr Hum Retrovirol 5:37–45Google Scholar
  17. 17.
    Kunstmann E, Hardt C, Treitz H, Suerbaum S, Fallere G, Peitz U, Schmiegel W, Epplen JT (2002) In the European population HLA-class II genes are not associated with Helicobacter pylori infection. Eur J Gastroenterol Hepatol 14:49–53CrossRefPubMedGoogle Scholar
  18. 18.
    Lee JE, Lu M, Mansfield PF, Reveille JD, Sample D, Odato M, Babiak-Vazquez A, Glober GA, Lynch PM, Steinbach G (1997) Genomic HLA-DQB1*0301 status predicts the serologic response to helicobacter pylori infection in patients with gastrointestinal malignancy (abstract). Gastroenterology 112:A1024Google Scholar
  19. 19.
    Magnusson PKE, Enroth H, Eriksson I, Held M, Nyrén, Engstrand L, Hansson L-H, Gyllensten UB (2001) Gastric cancer and human leukocyte antigen: distinct DQ and DR alleles are associated with development of gastric cancer and infection by Helicobacter pylori. Cancer Res 61:2684–2689PubMedGoogle Scholar
  20. 20.
    Mann DL, Murray C, O’Donnell M, Blattner WA, Goedert JJ (1990) HLA antigen frequencies in HIV-1-related Kaposi’s sarcoma. J Acquir Immune Defic Syndr Hum Retrovirol 3 [Suppl 1]:51–55Google Scholar
  21. 21.
    Müller CR (2000) Populationsgenetische Parameter der Gewebemerkmale der deutschen Bevölkerung und ihre Anwendung bei der Suche nach nicht-verwandten Blutstammzellspendern, thesis. University of UlmGoogle Scholar
  22. 22.
    Müller CR, Ehninger G, Goldmann SF (2003) Gene and haplotype frequencies for the loci HLA-A, HLA-B and HLA-DR based on over 13,000 German blood donors. Hum Immunol 64:137–151CrossRefPubMedGoogle Scholar
  23. 23.
    Musshoff K (1977) Clinical staging classification of non-Hodgkin’s lymphomas. Strahlentherapie 153:218–221PubMedGoogle Scholar
  24. 24.
    Neubauer A, Thiede C, Morgner A, Alpen B, Ritter M, Neubauer B, Wundisch T, Ehninger G, Stolte M, Mayerdorffer E (1997) Cure of Helicobacter pylori infection and duration of remission of low-grade gastric mucosa-associated lymphoid tissue lymphoma. J Natl Cancer Inst 89:1350–1305PubMedGoogle Scholar
  25. 25.
    Otter R, Gerrits WB, vd Sandt MM, Hermans J, Willemze R (1989) Primary extranodal and nodal non-Hodgkin’s lymphoma. A survey of a population-based registry. Eur J Cancer Clin Oncol 25:1203–1210PubMedGoogle Scholar
  26. 26.
    Parsonnet J, Hansen S, Rodriguez L, Gelb AB, Warnke RA, Jellum E, Orentreci N, Vogelman JH, Friedman GD (1994) Helicobacter pylori infection and gastric lymphoma. N Engl J Med 330:1267–1271PubMedGoogle Scholar
  27. 27.
    Radaszkiewicz T, Dragosics B, Bauer P (1992) Gastrointestinal malignant lymphomas of the mucosa-associated lymphoid tissue: factors relevant to prognosis. Gastroenterology 102:1628–1638Google Scholar
  28. 28.
    Rigopoulou D, Martinez-Laso J, Martinez-Tello F, Alcaide JF, Benmamar D, Hawkins F, Arnaiz-Villena A (1994) Both class I and class II HLA antigens are thyroid cancer susceptibility factors. Tissue Antigens 43:281–285PubMedGoogle Scholar
  29. 29.
    Rosen ST, Radvany R, Roenigk H Jr, Terasaki PI, Bunn PA Jr (1985) Human leukocyte antigens in cutaneous T cell lymphoma. J Am Acad Dermatol 12:531–534PubMedGoogle Scholar
  30. 30.
    Rovini D, Sacchini V, Codazzi V, Vaglini M, Illeni MT (1984) HLA antigen frequencies in malignant melanoma patients. A second study. Tumori 70:29–33PubMedGoogle Scholar
  31. 31.
    Santolaria S, Barrios Y, Benito R, Piazuelo E, Quintero E, Lanas A (2001) Helicobacter pylori and immunogenetic factors of the host: relevance of the HLADQA1 *0102 and *0301 alleles in peptic ulcer. Gastroenterol Hepatol 24:117–121PubMedGoogle Scholar
  32. 32.
    Seeberger H, Starostik P, Schwarz S, Knorr C, Kalla J, Ott G, Muller-Hermelink HK, Greiner A (2001) Loss of Fas (CD95/APO-1) regulatory function is an important step in early MALT-type lymphoma development. Lab Invest 81:977–986PubMedGoogle Scholar
  33. 33.
    Terasaki PI, McClelland JD (1964) Microdroplet assay of human serum cytotoxins. Nature 204:998–1000Google Scholar
  34. 34.
    Tokuc R, Akdas A, Ozerkan K, Remzi D (1987) Association between HLA antigens and bladder tumors. Eur Urol 13:207–209PubMedGoogle Scholar
  35. 35.
    Zhu XN, Chen R, Kong FH, Liu W (1990) Human leukocyte antigens -A, -B, -C, and -DR and nasopharyngeal carcinoma in northern China. Ann Otol Rhinol Laryngol 99:286–287PubMedGoogle Scholar

Copyright information

© Springer-Verlag 2004

Authors and Affiliations

  • Peter Reimer
    • 1
    Email author
  • Wolfgang Fischbach
    • 2
  • Maria-Elisabeth Goebeler
    • 1
  • Michael Rupert Kraus
    • 1
  • Shraga Goldmann
    • 3
  • Carlheinz Müller
    • 4
  • Martin Wilhelm
    • 5
  1. 1.Medizinische PoliklinikUniversitaet WuerzburgWuerzburgGermany
  2. 2.Medizinische Klinik IIKlinikum AschaffenburgAschaffenburgGermany
  3. 3.Abteilung für Transplantationsimmunologie, Institut UlmDRK-Blutspendedienst Baden-WuerttembergUlmGermany
  4. 4.Zentrales Knochenmarkspender-Register Deutschland (ZKRD)Helmholtzstr. 10UlmGermany
  5. 5.Medizinische Klinik 5Klinikum NordNuernbergGermany

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