Annals of Hematology

, Volume 83, Issue 2, pp 124–126

Clonal relationship in multifocal non-Hodgkin’s lymphoma of mucosa-associated lymphoid tissue (MALT)

  • B. Alpen
  • T. Wündisch
  • J. Dierlamm
  • G. Börsch
  • M. Stolte
  • A. Neubauer
Case Report


To elucidate the progression of gastric marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT) type, we analyzed a case presenting simultaneously with MALT lymphoma of the stomach and lung, and a gastric high-grade diffuse large lymphoma. The rearranged immunoglobulin heavy chain (IgH) variable regions were analyzed using a polymerase chain reaction (PCR)-based assay. Clonal relationship was shown between the gastric high-grade and the pulmonary low-grade lymphoma. The gastric MALT lymphoma was not related to the other manifestations. Translocation t(11;18) was not detected in the gastric high-grade lymphoma. MALT lymphomas at various locations and with different histologies may derive from a common precursor cell. Lymphomas at identical sites may have different stem cells.


MALT IgH t(11;18) 


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Copyright information

© Springer-Verlag 2004

Authors and Affiliations

  • B. Alpen
    • 1
    • 5
  • T. Wündisch
    • 1
  • J. Dierlamm
    • 2
  • G. Börsch
    • 3
  • M. Stolte
    • 4
  • A. Neubauer
    • 1
  1. 1.Department for Internal Medicine, Hematology, Oncology, ImmunologyHospital of the Philipps UniversityMarburgGermany
  2. 2.Department for Oncology and HematologyUniversity-Hospital EppendorfHamburgGermany
  3. 3.Elisabeth HospitalEssenGermany
  4. 4.Institute for PathologyHospital BayreuthBayreuthGermany
  5. 5.Department for RadiooncologyCharité Hospital of Humboldt UniversityBerlinGermany

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