Annals of Hematology

, Volume 83, Issue 2, pp 124–126

Clonal relationship in multifocal non-Hodgkin’s lymphoma of mucosa-associated lymphoid tissue (MALT)

  • B. Alpen
  • T. Wündisch
  • J. Dierlamm
  • G. Börsch
  • M. Stolte
  • A. Neubauer
Case Report

Abstract

To elucidate the progression of gastric marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT) type, we analyzed a case presenting simultaneously with MALT lymphoma of the stomach and lung, and a gastric high-grade diffuse large lymphoma. The rearranged immunoglobulin heavy chain (IgH) variable regions were analyzed using a polymerase chain reaction (PCR)-based assay. Clonal relationship was shown between the gastric high-grade and the pulmonary low-grade lymphoma. The gastric MALT lymphoma was not related to the other manifestations. Translocation t(11;18) was not detected in the gastric high-grade lymphoma. MALT lymphomas at various locations and with different histologies may derive from a common precursor cell. Lymphomas at identical sites may have different stem cells.

Keywords

MALT IgH t(11;18) 

References

  1. 1.
    Akagi T, Motegi M, Tamura A, Suzuki R, Hosokawa Y, Suzuki H, Ota H, Nakamura S, Morishima Y, Taniwaki M, Seto M (1999) A novel gene, MALT1 at 18q21, is involved in t(11;18)(q21;q21) found in low-grade B-cell lymphoma of mucosa-associated lymphoid tissue. Oncogene 18:5785–5794CrossRefPubMedGoogle Scholar
  2. 2.
    Auer IA, Gascoyne RD, Connors JM, Cotter FE, Greiner TC, Sanger WG, Horsman DE (1997) t(11;18)(q21;q21) is the most common translocation in MALT lymphomas. Ann Oncol 8:979–985Google Scholar
  3. 3.
    Cook GP, Tomlinson IM, Walter G, Riethman H, Carter NP, Buluwela L, Winter G, Rabbitts TH (1994) A map of the human immunoglobulin VH locus completed by analysis of the telomeric region of chromosome 14q. Nat Genet 7:162–168PubMedGoogle Scholar
  4. 4.
    Dierlamm J, Baens M, Wlodarska I, Stefanova-Ouzounova M, Hernandez JM, Hossfeld DK, De Wolf-Peeters C, Hagemeijer A, Van den Berghe H, Marynen P (1999) The apoptosis inhibitor gene API2 and a novel 18q gene, MLT, are recurrently rearranged in the t(11;18) associated with the mucosa-associated lymphoid tissue lymphomas. Blood 93:3601–3609PubMedGoogle Scholar
  5. 5.
    Dierlamm J, Baens M, Stefanova-Ouzounova M, Hinz K, Wlodarska I, Maes B, Steyls A, Driessen A, Verhoef G, Gaulard P, Hagemeijer A, Hossfeld DK, De Wolf-Peeters C, Marynen P (2000) Detection of t(11;18)(q21;q21) by interphase fluorescence in situ hybridization using API2 and MLT specific probes. Blood 96:2215–2218PubMedGoogle Scholar
  6. 6.
    Du MQ, Xu CF, Diss TC, Peng HZ, Wotherspoon AC, Isaacson PG, Pan LX (1996) Intestinal dissemination of gastric mucosa-associated lymphoid tissue lymphoma. Blood 88:4445–4451PubMedGoogle Scholar
  7. 7.
    Matolcsy A, Nagy M, Kisfaludy N, Kelenyi G (1999) Distinct clonal origin of low-grade MALT-type and high-grade lesions of a multifocal gastric lymphoma. Histopathology 34:6–8CrossRefPubMedGoogle Scholar
  8. 8.
    Ott G, Katzenberger T, Greiner A, Kalla J, Rosenwald A, Heinrich U, Ott MM, Muller-Hermelink HK (1997) The t(11;18)(q21;q21) chromosome translocation is a frequent and specific aberration in low-grade but not high-grade malignant non-Hodgkin’s lymphomas of the mucosa associated lymphoid tissue (MALT)-type. Cancer Res 57:3944–3948PubMedGoogle Scholar
  9. 9.
    Peng H, Du M, Diss TC, Isaacson PG, Pan L (1997) Genetic evidence for a clonal link between low and high-grade components in gastric MALT B-cell lymphoma. Histopathology 30:425–429PubMedGoogle Scholar
  10. 10.
    Starostik P, Patzner J, Greiner A, Schwarz S, Kalla J, Ott G, Muller-Hermelink HK (2002) Gastric marginal zone B-cell lymphomas of MALT type develop along 2 distinct pathogenetic pathways. Blood 99:3–9CrossRefPubMedGoogle Scholar
  11. 11.
    Thieblemont C, Berger F, Dumontet C, Moullet I, Bouafia F, Felman P, Salles G, Coiffier B (2000) Mucosa associated lymphoid tissue lymphoma is a disseminated disease in one third of 158 patients analyzed. Blood 95:802–806PubMedGoogle Scholar
  12. 12.
    Thiede C, Alpen B, Morgner A, Schmidt M, Ritter M, Ehninger G, Stolte M, Bayerdorffer E, Neubauer A (1998) Ongoing somatic mutations and clonal expansion after sure of Helicobacter pylori infection in gastric mucosa associated lymphoid tissue (MALT) B-cell lymphoma. J Clin Oncol 16:3822–3831PubMedGoogle Scholar
  13. 13.
    Tomlinson IM, Walter G, Marks JD, Llewelyn MB, Winter G (1992) The repertoire of human germline VH sequences reveals about fifty groups of VH segments with different hypervariable loops. J Mol Biol 227:776–798PubMedGoogle Scholar

Copyright information

© Springer-Verlag 2004

Authors and Affiliations

  • B. Alpen
    • 1
    • 5
  • T. Wündisch
    • 1
  • J. Dierlamm
    • 2
  • G. Börsch
    • 3
  • M. Stolte
    • 4
  • A. Neubauer
    • 1
  1. 1.Department for Internal Medicine, Hematology, Oncology, ImmunologyHospital of the Philipps UniversityMarburgGermany
  2. 2.Department for Oncology and HematologyUniversity-Hospital EppendorfHamburgGermany
  3. 3.Elisabeth HospitalEssenGermany
  4. 4.Institute for PathologyHospital BayreuthBayreuthGermany
  5. 5.Department for RadiooncologyCharité Hospital of Humboldt UniversityBerlinGermany

Personalised recommendations