Annals of Hematology

, Volume 83, Issue 2, pp 101–106 | Cite as

Early and late gastrointestinal complications after myeloablative and nonmyeloablative allogeneic stem cell transplantation

  • A. Schulenburg
  • K. Turetschek
  • F. Wrba
  • H. Vogelsang
  • H. T. Greinix
  • F. Keil
  • M. Mitterbauer
  • P. Kalhs
Original Article


Upper and lower gastrointestinal symptoms are major and serious complications after stem cell transplantation. Their main causes are gastrointestinal graft-versus-host disease (GVHD), infections, toxicity, or preexisting gastrointestinal diseases. The clinical presentation of each disease is nonspecific. The diagnostic procedure for this study included physical exam, stool cultures, endoscopy with biopsies, and abdominal computed tomography (CT). The study was designed prospectively with consecutive patients and performed at our institution in a clinical stem cell transplantation setting. Between January 1996 and September 2001, we analyzed 42 consecutive patients who had been admitted at our institution for gastrointestinal complaints after allogeneic stem cell transplantation for hematologic diseases. Diagnostic procedures revealed in decreasing order: GVHD (62%), gastritis/esophagitis (19%), cytomegalovirus (CMV) enteritis (11%), bacterial enteritis (6%), and toxic mucosal damage (2%). CT showed unspecific findings. Gastrointestinal GVHD and infectious colitis accounted for the majority of gastrointestinal complications after allogeneic stem cell transplantation in our patient population. The diagnosis was mainly based on endoscopically obtained biopsies.


Gastrointestinal complications Bone marrow transplantation 



Stem cell transplantation


Computed tomography


Graft-versus-host disease






World Health Organization


Bone marrow


Peripheral blood stem cells


Granulocyte colony-stimulating factor


Red blood cells


Deoxyribonucleic acid


Phosphate-buffered saline


Hounsfield unit


Polymerase chain reaction


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Copyright information

© Springer-Verlag 2004

Authors and Affiliations

  • A. Schulenburg
    • 1
  • K. Turetschek
    • 2
  • F. Wrba
    • 3
  • H. Vogelsang
    • 4
  • H. T. Greinix
    • 1
  • F. Keil
    • 1
  • M. Mitterbauer
    • 1
  • P. Kalhs
    • 1
  1. 1.Bone Marrow Transplantation, Department of Medicine IUniversity of ViennaViennaAustria
  2. 2.Department of RadiologyUniversity of ViennaViennaAustria
  3. 3.Department of PathologyUniversity of ViennaViennaAustria
  4. 4.Department of GastroenterologyUniversity of ViennaViennaAustria

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