Annals of Hematology

, Volume 83, Issue 2, pp 101–106 | Cite as

Early and late gastrointestinal complications after myeloablative and nonmyeloablative allogeneic stem cell transplantation

  • A. Schulenburg
  • K. Turetschek
  • F. Wrba
  • H. Vogelsang
  • H. T. Greinix
  • F. Keil
  • M. Mitterbauer
  • P. Kalhs
Original Article

Abstract

Upper and lower gastrointestinal symptoms are major and serious complications after stem cell transplantation. Their main causes are gastrointestinal graft-versus-host disease (GVHD), infections, toxicity, or preexisting gastrointestinal diseases. The clinical presentation of each disease is nonspecific. The diagnostic procedure for this study included physical exam, stool cultures, endoscopy with biopsies, and abdominal computed tomography (CT). The study was designed prospectively with consecutive patients and performed at our institution in a clinical stem cell transplantation setting. Between January 1996 and September 2001, we analyzed 42 consecutive patients who had been admitted at our institution for gastrointestinal complaints after allogeneic stem cell transplantation for hematologic diseases. Diagnostic procedures revealed in decreasing order: GVHD (62%), gastritis/esophagitis (19%), cytomegalovirus (CMV) enteritis (11%), bacterial enteritis (6%), and toxic mucosal damage (2%). CT showed unspecific findings. Gastrointestinal GVHD and infectious colitis accounted for the majority of gastrointestinal complications after allogeneic stem cell transplantation in our patient population. The diagnosis was mainly based on endoscopically obtained biopsies.

Keywords

Gastrointestinal complications Bone marrow transplantation 

Abbreviations

SCT

Stem cell transplantation

CT

Computed tomography

GVHD

Graft-versus-host disease

CMV

Cytomegalovirus

GI

Gastrointestinal

WHO

World Health Organization

BM

Bone marrow

PBSC

Peripheral blood stem cells

G-CSF

Granulocyte colony-stimulating factor

RBC

Red blood cells

DNA

Deoxyribonucleic acid

PBS

Phosphate-buffered saline

HU

Hounsfield unit

PCR

Polymerase chain reaction

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Copyright information

© Springer-Verlag 2004

Authors and Affiliations

  • A. Schulenburg
    • 1
  • K. Turetschek
    • 2
  • F. Wrba
    • 3
  • H. Vogelsang
    • 4
  • H. T. Greinix
    • 1
  • F. Keil
    • 1
  • M. Mitterbauer
    • 1
  • P. Kalhs
    • 1
  1. 1.Bone Marrow Transplantation, Department of Medicine IUniversity of ViennaViennaAustria
  2. 2.Department of RadiologyUniversity of ViennaViennaAustria
  3. 3.Department of PathologyUniversity of ViennaViennaAustria
  4. 4.Department of GastroenterologyUniversity of ViennaViennaAustria

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