Annals of Hematology

, Volume 81, Issue 6, pp 343–346

Successful antiviral treatment for fulminant reactivated hepatitis B after autologous stem cell transplantation and prophylaxis during subsequent allogeneic stem cell transplantation

  • M. Henkes
  • S. Martin
  • H. Einsele
  • W. Aulitzky
Case Report

DOI: 10.1007/s00277-002-0469-0

Cite this article as:
Henkes, M., Martin, S., Einsele, H. et al. Ann Hematol (2002) 81: 343. doi:10.1007/s00277-002-0469-0

Abstract.

The risk of severe hepatic damage due to reactivation of hepatitis B virus (HBV) infection after intensive myelosuppressive chemotherapy is well known. Two of the most evolved nucleotide analogues showing good activity against the hepatitis B virus are lamivudine and famciclovir. We report the successful therapeutic use of lamivudine and famciclovir for fulminant reactivated hepatitis B after autologous peripheral blood stem cell transplantation (PBSCT) and the subsequent prophylactic use of lamivudine during allogeneic blood stem cell transplantation (alloSCT) for chronic lymphocytic leukemia (CLL) in a 40-year-old patient. Antiviral therapy was well tolerated and no hematotoxicity occurred. Our observation warrants further investigation of antiviral therapy with famciclovir and lamivudine in HBV carriers receiving intensive myelosuppressive chemotherapy.

Lamivudine Famciclovir Hepatitis B virus infection Myeloablative radiochemotherapy High-dose chemotherapy Autologous blood stem cell transplantation Allogeneic blood stem cell transplantation Chronic lymphocytic leukemia 

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Copyright information

© Springer-Verlag 2002

Authors and Affiliations

  • M. Henkes
    • 1
  • S. Martin
    • 1
  • H. Einsele
    • 2
  • W. Aulitzky
    • 1
  1. 1.Department of Internal Medicine II, Robert-Bosch-Hospital, Auerbachstraße 110, 70376 Stuttgart, GermanyGermany
  2. 2.Department of Internal Medicine II, University Hospital, Tuebingen, GermanyGermany

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