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Annals of Hematology

, Volume 81, Issue 3, pp 174–177 | Cite as

Philadelphia-positive T-cell acute lymphoblastic leukemia with polymyositis, migratory polyarthritis and hypercalcemia following a chronic myeloid leukemia

  • M. Lima
  • J. Coutinho
  • L. Bernardo
  • M. dos Anjos Teixeira
  • C. Casais
  • Á. Canelhas
  • M. Queirós
  • A. Orfão
  • B. Justiça
Case Report

Abstract.

Transformation of chronic myeloid leukemia (CML) often results in acute myeloblastic or, less frequently, in precursor B-cell acute lymphoblastic leukemia (ALL). T-cell blast crisis is rare. Hypercalcemia has also been described as a rare complication of CML, but this usually occurs as a terminal event. Here we report a case of a 35-year-old woman who developed a CD4+/CD8+ T-cell ALL 2 years after the diagnosis of a typical Ph+ CML. Polymyositis and polyarthritis preceded by 4 months, and symptomatic hypercalcemia occurred just before blastic transformation, probably representing paraneoplastic manifestations of the disease.

T-cell acute lymphoblastic leukemia Chronic myeloid leukemia Philadelphia chromosome positivity Hypercalcemia Polymyositis 

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Copyright information

© Springer-Verlag 2002

Authors and Affiliations

  • M. Lima
    • 1
  • J. Coutinho
    • 1
  • L. Bernardo
    • 2
  • M. dos Anjos Teixeira
    • 1
  • C. Casais
    • 1
  • Á. Canelhas
    • 3
  • M. Queirós
    • 1
  • A. Orfão
    • 4
  • B. Justiça
    • 1
  1. 1.Department of Clinical Hematology, Hospital Geral de Santo António, Rua D Manuel II, s/n, 4099-001 Porto, PortugalPortugal
  2. 2.Department of Medicine, Hospital Geral de Santo António, Rua D Manuel II, s/n, 4099-001 Porto, PortugalPortugal
  3. 3.Department of Pathology, Hospital Geral de Santo António, Rua D Manuel II, s/n, 4099-001 Porto, PortugalPortugal
  4. 4.Department of Flow Cytometry, Hospital Clinico Universitario, Salamanca, SpainSpain

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