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Arcuate foramen: “Anatomical variation shape or adaptation legacy?”

  • Giulia Cossu
  • Louis-Marie Terrier
  • Christophe Destrieux
  • Stephane Velut
  • Patrick François
  • Ilyess Zemmoura
  • Aymeric AmelotEmail author
Original Article

Abstract

Purpose

The groove of the vertebral artery on the posterior arch of the atlas (sulcus arteriae vertebralis) may become a complete or partial osseous foramen: the arcuate foramen. The presence of a complete or partial arcuate foramen is a rare anatomical variant described in a minority of patients and it seems to be associated with vertigo, vertebro-basilar insufficiency, posterior circulation strokes, and musculoskeletal pain. As the number and morphology of cervical vertebrae is highly preserved, we questioned about its significance from an evolutionary point of view. We thus investigated through an extensive literature review if the arcuate foramen is a pure anatomical variation shape or if it might represent an adaptation legacy.

Methods

We observed five atlas of an extinct species, the Late Pleistocene Mammoths (M. primigenius), and we compared them with five atlas of a closely related existent species, the African elephant (L. africana).

Results

All the mammoths’ atlas had an arcuate foramen through which the vertebral artery passed before turning anteriorly and becoming intradural. This foramen was not present in elephants’ atlas, where only a groove was observed, such as in the majority of patients.

Conclusion

We would like to raise the hypothesis that this peculiar morphology of mammoths’ atlas might have contributed, in association with other factors, to their precocious extinction and that the arcuate foramen might represent a disadvantage in the evolutionary process, with a low prevalence in humans being the result of a natural selection.

Keywords

Atlas Arcuate foramen Mammoth Elephant Extinction Evolution Cervical vertebra Vertebral artery Groove 

Notes

Author contributions

GC, AA, and LMT design and conceptualization of the study, GC, AA, LMT, IZ, and PF analysis of the data, GC, AA, IZ, PF, SV, and CD interpretation of the data, GC, AA, LMT, IZ, PF, SV, and CD drafting of the manuscript, AA and GC writing of the manuscript, and GC, AA, LMT, IZ, PF, SV, and CD revision of the manuscript for intellectual content. AA and GC are responsible for the overall content as guarantor.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no personal conflicts of interest and no institutional financial interest in any drugs, materials, or devices described in this manuscript. The authors have no financial disclosures to report. In addition, all patients gave their informed consent for any medical and scientific investigations. This paper has not been published previously, is not under consideration for publication elsewhere. All authors are responsible for reported research.

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Copyright information

© Springer-Verlag France SAS, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of NeurosurgeryBretonneau University HospitalToursFrance
  2. 2.Department of NeurosurgeryLausanne University HospitalLausanneSwitzerland
  3. 3.Department of NeurosurgeryLa Pitié-Salpétrière University HospitalParisFrance

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