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Analysis of the development of human foetal nasal turbinates using CBCT imaging

  • Rieko Asaumi
  • Yoko Miwa
  • Taisuke Kawai
  • Iwao Sato
Original Article
  • 12 Downloads

Abstract

Purpose

The morphological structure of the nasal cavity (NC) is important for endoscopic surgical treatment. The location of nasal turbinates, including the superior turbinate (ST), middle turbinate (MT) and inferior turbinate (IT), are well presented during the formation of the human NC in cone beam CT (CBCT) images. There is a complex relationship between the nasal sinuses, the maxillary sinus (MS), ethmoidal sinus and sphenoid sinus, during formation of the NC structure at the morphological level. There is a need to clearly define the relationships of these nasal elements at the ossification level, during development.

Methods

We investigated the three-dimensional construction of human foetal NC elements, including ST, MT, IT and vomer, using CBCT images from 16 weeks gestation (E16) to E31 (25 foetuses) and compared it to histochemical observations (E25).

Results

At the stage of ossification, the studied elements are elongated in the posterior region near the sphenoidal bone, showing that the locations of the ST, MT, and IT are important during formation of the NC. CBCT analysis revealed that the horizontal and vertical directions of nasal turbinates affect the formation of the human NC.

Conclusion

The location and elongated development of the MT is one of the most important elements for NC formation. The relationship between the nasal sinus and nasal turbine at the level of ossification may provide useful information in clinical treatment of children.

Keywords

CBCT Nasal turbinate Nasal cavity Maxillary sinus Foetus 

Notes

Author contributions

Protocol/project development IS, RA. Data collection and management RA, TK. Data analysis YM. Manuscript writing/editing RA, TK, IS.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflicts of interest.

References

  1. 1.
    Arredondo de Arreola G, López Serna N, de Hoyos Parra R, Arreola Salinas MA (1996) Morphogenesis of the lateral nasal wall from 6 to 36 weeks. Otolaryngol Head Neck Surg 114:54–60CrossRefGoogle Scholar
  2. 2.
    Arslan H, Aydinlioğlu A, Bozkurt M, Egeli E (1999) Anatomic variations of the paranasal sinuses: CT examination for endoscopic sinus surgery. Auris Nasus Larynx 26:39–48CrossRefGoogle Scholar
  3. 3.
    Bingham B, Wang RG, Hawke M, Kwok P (1991) The embryonic development of the lateral nasal wall from 8 to 24 weeks. Laryngoscope 101:992–997CrossRefPubMedGoogle Scholar
  4. 4.
    Botti S, Rumeau C, Gallet P, Jankowski R (2017) Vomero-premaxillary joint: a marker of evolution of the species. Eur Ann Otorhinolaryngol Head Neck Dis 134(2):83–87.  https://doi.org/10.1016/j.anorl.2016.11.002. (Epub 2017 Jan 20)CrossRefGoogle Scholar
  5. 5.
    Cankaya H, Egeli E, Kutluhan A, Kiriş M (2001) Pneumatization of the concha inferior as a cause of nasal obstruction. Rhinology 39:109–111PubMedGoogle Scholar
  6. 6.
    Herzallah IR, Saati FA, Marglani OA, Simsim RF (2016) Retromaxillary pneumatization of posterior ethmoid air cells: novel description and surgical implications. Otolaryngol Head Neck Surg 155:340–346.  https://doi.org/10.1177/0194599816639943. (Epub 2016)CrossRefPubMedGoogle Scholar
  7. 7.
    Jankowski R (2013) The evo-devo origin of the nose, anterior skull base and midface. Springer, ParisCrossRefGoogle Scholar
  8. 8.
    Jankowski R, Rumeau C, de Saint Hilaire T, Tonnelet R, Nguyen DT, Gallet P, Perez M (2016) The olfactory fascia: an evo-devo concept of the fibrocartilaginous nose. Surg Radiol Anat 38(10):1161–1168. (Epub 2016)CrossRefPubMedGoogle Scholar
  9. 9.
    Jankowski R, Márquez S (2016) Embryology of the nose: the evo-devo concept. World J Otorhinolaryngol 6(2): 33–40.  https://doi.org/10.5319/wjo.v6.i2.33 CrossRefGoogle Scholar
  10. 10.
    Jankowski R, Perrot C, Nguyen DT, Rumeau C (2016) Structure of the lateral mass of the ethmoid by curved stacking of endoturbinal elements. Eur Ann Otorhinolaryngol Head Neck Dis 133(5):325–329.  https://doi.org/10.1016/j.anorl.2016.07.007. (Epub 2016)CrossRefPubMedGoogle Scholar
  11. 11.
    Kantarci M, Karasen RM, Alper F, Onbas O, Okur A, Karaman A (2004) Remarkable anatomic variations in paranasal sinus region and their clinical importance. Eur J Radiol 50:296–302CrossRefPubMedGoogle Scholar
  12. 12.
    Kim SK, Heo GE2, Seo A, Na Y, Chung SK (2014) Correlation between nasal airflow characteristics and clinical relevance of nasal septal deviation to nasal airway obstruction. Respir Physiol Neurobiol 192:95–101.  https://doi.org/10.1016/j.resp.2013.12.010. (Epub 2013)CrossRefPubMedGoogle Scholar
  13. 13.
    Lee KB, Jeon YS, Chung SK, Kim SK (2016) Effects of partial middle turbinectomy with varying resection volume and location on nasal functions and airflow characteristics by CFD. Comput Biol Med 77:214–221.  https://doi.org/10.1016/j.compbiomed.2016.08.014. (Epub 2016)CrossRefPubMedGoogle Scholar
  14. 14.
    Liu ZP, Luo JW, Xu GZ, Gao L, Yi JL, Huang XD, Qu Y, Wang K, Zhang SP, Xiao JP (2017) Failure patterns and prognostic factors of patients with primary mucosal melanoma of the nasal cavity and paranasal sinuses. Acta Otolaryngol 137:1115–1120.  https://doi.org/10.1080/00016489.2017.1336797. (Epub 2017)CrossRefPubMedGoogle Scholar
  15. 15.
    Márquez S, Tessema B, Clement PA, Schaefer SD (2008) Development of the ethmoid sinus and extramural migration: the anatomical basis of this paranasal sinus. Anat Rec (Hoboken) 291(11):1535–1553.  https://doi.org/10.1002/ar.20775 CrossRefGoogle Scholar
  16. 16.
    Marquez S, Pagano A, Lawson W, Laitman J (2016) Evolution of the human nasal respiratory tract: nose and paranasal sinuses. Sataloff’s comprehensive textbook of otolaryngology: head and neck surgery (Rhinology/Allergy and Immunology), 2, JP Medical Ltd., New Delhi, 17–42Google Scholar
  17. 17.
    Moore W (2009) The mammalian skull. Biological structure and function. Cambridge University Press, CambridgeGoogle Scholar
  18. 18.
    Nakashima T, Kimmelman CP, Snow JB Jr (1984) Structure of human fetal and adult olfactory neuroepithelium. Arch Otolaryngol 110(10):641–646CrossRefPubMedGoogle Scholar
  19. 19.
    Neskey D, Eloy JA, Casiano RR (2009) Nasal, septal, and turbinate anatomy and embryology. Otolaryngol Clin North Am 42(2):193–205.  https://doi.org/10.1016/j.otc.2009.01.008.CrossRefPubMedGoogle Scholar
  20. 20.
    Schepelmann K (1990) Erythropoietic bone marrow in the pigeon: development of its distribution and volume during growth and pneumatization of bones. J Morphol 203(1):21–34CrossRefPubMedGoogle Scholar
  21. 21.
    Selcuk A, Ozcan KM, Ozcan I, Dere H (2008) Bifid inferior turbinate: a case report. J Laryngol Otol 122:647–649. (Epub 2007)CrossRefPubMedGoogle Scholar
  22. 22.
    Som PM, Naidich TP (2013) Illustrated review of the embryology and development of the facial region, part 1: early face and lateral nasal cavities. Am J Neuroradiol 34:2233–2240.  https://doi.org/10.3174/ajnr. (A3415. Epub 2013)CrossRefPubMedGoogle Scholar
  23. 23.
    Som PM, Naidich TP (2014) Illustrated review of the embryology and development of the facial region, part 2: late development of the fetal face and changes in the face from the newborn to adulthood. Am J Neuroradiol 35:10–18.  https://doi.org/10.3174/ajnr.A3414. (Epub 2013)CrossRefPubMedGoogle Scholar
  24. 24.
    Stenner M, Rudack C (2014) Diseases of the nose and paranasal sinuses in child. GMS Curr Top Otorhinolaryngol Head Neck Surg 13:Doc10.  https://doi.org/10.3205/cto000113. (eCollection 2014)CrossRefPubMedPubMedCentralGoogle Scholar
  25. 25.
    Streeter GL (1951) Developmental horizons in human embryos. Age groups XI to XXIII Embryol Reprint Vol II Carnegie Inst, WashingtonGoogle Scholar
  26. 26.
    Uzun L, Ugur MB, Savranlar A, Mahmutyazicioglu K, Ozdemir H, Beder LB (2004) Classification of the inferior turbinate bones: a computed tomography study. Eur J Radiol 51:241–245CrossRefPubMedGoogle Scholar
  27. 27.
    Wolf G, Anderhuber W, Kuhn F (1993) Development of the paranasal sinuses in children: implications for paranasal sinus surgery. Ann Otol Rhinol Laryngol 102:705–711CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag France SAS, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Oral and Maxillofacial Radiology, School of Life Dentistry at TokyoThe Nippon Dental UniversityTokyoJapan
  2. 2.Department of Anatomy, School of Life Dentistry at TokyoThe Nippon Dental UniversityTokyoJapan

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