CardioVascular and Interventional Radiology

, Volume 22, Issue 4, pp 321–325

Pulmonary hemorrhage: Imaging with a new magnetic resonance blood pool agent in conjunction with breathheld three-dimensional magnetic resonance angiography

  • Dominik Weishaupt
  • Paul R. Hilfiker
  • Michaela Schmidt
  • Jörg F. Debatin
Laboratory Investigation
  • 51 Downloads

Abstract

Purpose: To describe the three-dimensional magnetic resonance angiography (3D MRA) imaging appearance of the pulmonary arteries following administration of a superparamagnetic iron oxide blood pool agent to human volunteers, and to demonstrate in an animal model (pigs) how this technique can be used to detect pulmonary parenchymal hemorrhage.

Methods: Two volunteers were examined following the intravenous administration of a superparamagnetic iron oxide blood pool agent (NC100150 Injection, Nycomed Amersham Imaging, Wayne, PA, USA). T1-weighted 3D gradient recalled echo (GRE) image sets (TR/TE 5.1/1.4 msec, flip angle 30°) were acquired breathheld over 24 sec. To assess the detectability of pulmonary bleeding with intravascular MR contrast, pulmonary parenchymal injuries were created in two animals under general anesthesia, and fast T1-weighted 3D GRE image sets collected before and after the injury.

Results: Administration of the intravascular contrast in the two volunteers resulted in selective enhancement of the pulmonary vasculature permitting complete visualization and excellent delineation of central, segmental, and subsegmental arteries. Following iatrogenic injury in the two animals, pulmonary hemorrhage was readily detected on the 3D image sets.

Conclusion: The data presented illustrate that ultrafast 3D GRE MR imaging in conjunction with an intravenously administered intravascular blood pool agent can be used to perform high-quality pulmonary MRA as well as to detect pulmonary hemorrhage.

Key words

Contrast media Pulmonary angiography Pulmonary hemorrhage MR angiography 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Anzai Y, Prince MR, Chenevert TL, Maki JH, Londy F, London M, McLachlan SJ (1997) MR angiography with superparamagnetic iron oxide blood pool agent. J Magn Reson Imaging 7:209–214PubMedCrossRefGoogle Scholar
  2. 2.
    Leung DA, McKinnon GC, Davis CP, Pfammatter T, Krestin GP, Debatin JF (1996) Breath-hold contrast-enhanced, three-dimensional MR angiography. Radiology 201:569–571Google Scholar
  3. 3.
    Steiner P, McKinnon GC, Romanowski B, Goehde SC, Hany T, Debatin JF (1997) Contrast-enhanced, ultrafast 3D MR angiography in a single breath-hold: Initial assessement of imaging performance. J Magn Reson Imaging 7:177–182PubMedCrossRefGoogle Scholar
  4. 4.
    Frazer RG, Paré P, Paré PD (1988) Diseases of the thorax caused by eternal physical agents. In: Fraser RG, Paré P, Paré PD (eds) Diagnosis of Diseases of the Chest, 3rd edn. WB Saunders, Philadelphia, pp 394–396Google Scholar
  5. 5.
    Primack SL, Miller RR, Müller NL (1995) Diffuse pulmonary hemorrhage: Clinical, and imaging features. AJR 164:295–300PubMedGoogle Scholar
  6. 6.
    Hirschberg B, Biran I, Glazer M, Kramer MR (1997) Hemoptysis: Etiology, evaluation and outcome in a tertiary referral hospital. Chest 112:440–444CrossRefGoogle Scholar
  7. 7.
    McGuinness G, Beacher JR, Harkin TJ, Garay SM, Rom WN, Naidich DP (1994) Hemoptysis: Prospective high-resolution CT/bronchoscopic correlation. Chest 105:1155–1162PubMedCrossRefGoogle Scholar
  8. 8.
    Wildermuth S, Dubno B, Romanowski J, Borseth A, Annweiler A, Debatin JF (1998) Open-label, phase 1 trial of a new blood pool contrast agent (NC100150) in 12 healthy volunteers: Safety and vascular imaging characteristics. Sixth Annual Scientific Meeting of the International Society of Magnetic Resonance in Medicine (ISMRM), Sidney, 1998Google Scholar
  9. 9.
    Shott S (1990) Nonparametric statistics. In: Statistics for Health Professionals. WB Saunders, Philadelphia, pp 229–267Google Scholar
  10. 10.
    Heid O, Deimling M, Huk WJ (1995) Ultra-rapid gradient echo imaging. J Magn Reson Imaging 33:143–149Google Scholar
  11. 11.
    Prince MR (1994) Gadolinium-enhanced MR aortography. Radiology 191:155–164PubMedGoogle Scholar
  12. 12.
    Prince MR, Yucel EK, Kaufman JA, Harrison DC, Geller SC (1993) Dynamic gadolinium-enhanced three-dimensional abdominal MR arthrography. J Magn Reson Imaging 3:877–881PubMedCrossRefGoogle Scholar
  13. 13.
    Holland GA, Dougherty L, Carpenter JP, Axel L (1996) Breath-hold ultrafast three-dimensional gadolinium-enhanced MR angiography of the aorta and the renal and other visceral arteries. AJR 166:971–981PubMedGoogle Scholar
  14. 14.
    Snidow JJ, Johnson MS, Harris VJ, Margosian PM, Aisen AM, Lalka SG, Cikrit DF, Trerotola SO (1996) Three-dimensional gadolinium-enhanced MR angiography of aortoiliac inflow assessment plus renal artery screening in a single breath hold. Radiology 198:725–732PubMedGoogle Scholar
  15. 15.
    Hany TF, Debatin JF, Leung DA, Pfammatter T (1997) Evaluation of aortoiliac and renal arteries: Comparison of breath-hold, contrast-enhanced, three-dimensional MR angiography with conventional catheter angiography. Radiology 204:357–362PubMedGoogle Scholar
  16. 16.
    Meaney JF, Weg JG, Chenevert TL, Stafford-Johnson D, Hamilton BH, Prince MR (1997) Diagnosis of pulmonary embolism with magnetic resonance angiography. N Engl J Med 336:1422–1427PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag 1999

Authors and Affiliations

  • Dominik Weishaupt
    • 1
  • Paul R. Hilfiker
    • 1
  • Michaela Schmidt
    • 1
  • Jörg F. Debatin
    • 1
  1. 1.Institute of Diagnostic RadiologyUniversity Hospital ZurichZurichSwitzerland

Personalised recommendations