CardioVascular and Interventional Radiology

, Volume 24, Issue 2, pp 99–105 | Cite as

Endoluminal Treatment of Ruptured Abdominal Aortic Aneurysm with Small Intestinal Submucosa Sandwich Endografts: A Pilot Study in Sheep

  • Katsuyuki Yamada
  • Dusan Pavcnik
  • Barry T. Uchida
  • Hans A. Timmermans
  • Christopher L. Corless
  • Qiang Yin
  • Koichiro Yamakado
  • Joong Wha Park
  • Josef Rösch
  • Frederick S. Keller
  • Morio Sato
  • Ryusaku Yamada
Laboratory Investigations



To evaluate efficacy of small intestinal submucosa (SIS) Sandwich endografts for the treatment of acute rupture of abdominal aortic aneurysms (AAA) and to explore the short-term reaction of the aorta to this material.


In eight adult sheep, an infrarenal AAA was created transluminally by dilation of a short Palmaz stent. In six sheep, the aneurysm was then ruptured by overdilation of the stent with a large angioplasty balloon. Two sheep with AAAs that were not ruptured served as controls. A SIS Sandwich endograft, consisting of a Z stent frame with 5 bodies and covered inside and out with SIS, was used to exclude the ruptured and non-ruptured AAAs. Follow-up aortography was done immediately after the procedure and before sacrifice at 4, 8, or 12 weeks. Autopsy and histologic studies followed.


Endograft placement was successful in all eight sheep. Both ruptured and non-ruptured AAAs were successfully excluded. Three animals with AAA rupture developed hind leg paralysis due to compromise of the arterial supply to the lower spinal cord and were sacrificed 1 day after the procedure. In five animals, three with rupture and two controls, follow-up aortograms revealed no aortic stenoses and no perigraft leaks. Gross and histologic studies revealed incorporation of the endografts into the aortic wall with replacement of SIS by dense neointima that was completely endothelialized in areas where the endograft was in direct contact with the aortic wall. In central portions of the endograft, in contact with the thrombosed aneurysm, endothelialization was incomplete even at 12 weeks.


The SIS Sandwich endografts effectively excluded simple AAAs and ruptured AAAs. They were rapidly incorporated into the aortic wall. A detailed long-term study is warranted.

Key words

Aortic aneurysm Aneurysm rupture Endoluminal treatment Endovascular grafts Biomaterials small intestinal submucosa Animal models 


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Copyright information

© Springer-Verlag New York, Inc. 2001

Authors and Affiliations

  • Katsuyuki Yamada
    • 1
  • Dusan Pavcnik
    • 1
  • Barry T. Uchida
    • 1
  • Hans A. Timmermans
    • 1
  • Christopher L. Corless
    • 2
  • Qiang Yin
    • 3
  • Koichiro Yamakado
    • 1
  • Joong Wha Park
    • 1
  • Josef Rösch
    • 1
  • Frederick S. Keller
    • 1
  • Morio Sato
    • 4
  • Ryusaku Yamada
    • 5
  1. 1.Dotter Interventional Institute, Oregon Health Sciences UniversityPortlandUSA
  2. 2.Department of PathologyOregon Health Sciences UniversityPortlandUSA
  3. 3.Department of SurgeryOregon Health Sciences UniversityPortlandUSA
  4. 4.Department of RadiologyWakayama Medical CollegeWakayama-shi, WakayamaJapan
  5. 5.Department of RadiologyOsaka City University School of MedicineOsakaJapan

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