CardioVascular and Interventional Radiology

, Volume 43, Issue 2, pp 196–203 | Cite as

125I Irradiation Stent for Hepatocellular Carcinoma with Main Portal Vein Tumor Thrombosis: A Systematic Review

  • Lei Zhang
  • Bo Hu
  • Wei Li
  • Peng Huang
  • Shen Zhang
  • Bin-Yan ZhongEmail author
  • Cai-Fang NiEmail author


A systematic review was conducted to provide an overview of the efficacy and safety of 125I irradiation stent placement for patients with hepatocellular carcinoma (HCC) and main portal vein tumor thrombosis (MPVTT). Six studies with 406 patients were included in the final analysis. The median overall survival for patients treated with 125I irradiation stent placement was 10.3 months. The most common radiation-related adverse event was leukopenia. The stent-related adverse events consisted of fever, abdominal pain, hemorrhage, and anorexia. No stent or seed migration was reported. Overall, the use of an 125I irradiation stent has the potential to act as an alternative therapy for patients with HCC with MPVTT.


Hepatocellular carcinoma Portal vein tumor thrombosis Radioactive stent Endovascular brachytherapy Systematic review 





This study was supported by the National Natural Science Foundation of China (81901847) and the Suzhou Science and Technology Youth Plan (KJXW2018003). Funding source had no involvement in the financial support for the conduct of the research and preparation of the article.

Compliance with Ethical Standards

Conflict of interest

On behalf of all authors, the corresponding authors state that there is no conflict of interest.

Consent for Publication

For this type of study, consent for publication is not required.

Human and Animal Rights

This article does not contain any studies with human participants or animals performed by any of the authors.

Informed Consent

For this type of study, informed consent is not required.


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© Springer Science+Business Media, LLC, part of Springer Nature and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE) 2019

Authors and Affiliations

  1. 1.Department of Interventional RadiologyThe First Affiliated Hospital of Soochow UniversitySuzhouChina

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