CardioVascular and Interventional Radiology

, Volume 42, Issue 12, pp 1786–1794 | Cite as

Preclinical Evaluation of the Accero Stent: Flow Remodelling Effect on Aneurysm, Vessel Reaction and Side Branch Patency

  • Ruben Mühl-BenninghausEmail author
  • Rabie Abboud
  • Andeas Ding
  • Stefanie Krajewski
  • Andreas Simgen
  • Toshiki Tomori
  • Hagen Bomberg
  • Umut Yilmaz
  • Christoph Brochhausen
  • Wolfgang Reith
  • Giorgio Cattaneo
Laboratory Investigation



It has been hypothesized that microstents which are used to prevent coil protrusion in the treatment of cerebral aneurysms may have flow diverting and therefore occlusive effects. In a rabbit elastase aneurysm model, we investigated the aneurysm occlusion rate and vessel reaction of a braided Accero stent prototype with porosity in the lower range of other available (non-flow-diverter) microstents.


Ten aneurysms were induced the right subclavian artery in New Zealand white rabbits and treated with the Accero stent prototype. In each subject, a second stent was implanted in the abdominal aorta to cover the origins of branch arteries. Angiographic follow-up and explantation of the devices and aneurysms for histological analysis were performed after 3 months (n = 5) and 6 months (n = 5).


Grades I (< 50%) and II (> 50%) occlusion rates were observed in 9 (90%) and 1 (10%) of ten aneurysms treated with the stent device. The mean reduction in contrast filling at 6 months was 42.1% (p = .02). Neointima thickness was significantly higher in the subclavian artery than in the abdominal aorta after 3 (p = .03), whereas not after 6 months (p = .1). No cases of inadequate wall apposition, branch artery occlusion or stent thrombosis were observed.


The present study showed flow remodelling properties of the device prototype with progredient aneurysm occlusion. A larger in vivo study with induced aneurysm should be done to confirm these results.


Stent Flow diverter Aneurysm Rabbit aneurysm model 



This work was supported by the German Ministry of Economic Affairs and Energy (Grant No KF2335804AJ2) and partially funded by Acandis GmbH, Pforzheim, Germany.

Compliance with Ethical Standards

Conflict of interest

Giorgio Cattaneo was engineer at the company Acandis GmbH until August 2019, Andreas Ding is engineer at the company Acandis GmbH (Pforzheim, Germany). Both served as proctors during this study.

Ethical Approval

All applicable international, national and/or institutional guidelines for the care and use of animals were followed. All procedures performed in studies involving animals were in accordance with the ethical standards of the institution or practice at which the studies were conducted. This study obtained approval by the local animal protection committee (No. 44/13).

Supplementary material

270_2019_2345_MOESM1_ESM.docx (48 kb)
Supplementary material 1 (DOCX 48 kb)


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE) 2019

Authors and Affiliations

  • Ruben Mühl-Benninghaus
    • 1
    Email author
  • Rabie Abboud
    • 1
  • Andeas Ding
    • 2
  • Stefanie Krajewski
    • 3
  • Andreas Simgen
    • 1
  • Toshiki Tomori
    • 1
  • Hagen Bomberg
    • 4
  • Umut Yilmaz
    • 1
  • Christoph Brochhausen
    • 5
  • Wolfgang Reith
    • 1
  • Giorgio Cattaneo
    • 6
  1. 1.Department of NeuroradiologySaarland University HospitalHomburg/SaarGermany
  2. 2.Acandis GmbHPforzheimGermany
  3. 3.Department of Thoracic, Cardiac and Vascular SurgeryUniversity Hospital TübingenTübingenGermany
  4. 4.Department of Anaesthesiology, Intensive Care Medicine and Pain MedicineSaarland University HospitalHomburg/SaarGermany
  5. 5.Department of PathologyUniversity of RegensburgRegensburgGermany
  6. 6.Institute for Biomedical EngineeringUniversity of StuttgartStuttgartGermany

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