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Balloon-Expandable Biodegradable Stents Versus Self-Expandable Metallic Stents: A Comparison Study of Stent-Induced Tissue Hyperplasia in the Rat Urethra

  • Jung-Hoon Park
  • Tae-Hyung Kim
  • Young Chul Cho
  • Nader Bakheet
  • Seung Ok Lee
  • Seong-Hun KimEmail author
  • Kun Yung KimEmail author
Laboratory Investigation
  • 37 Downloads

Abstract

Purpose

To compare the degrees of stent-induced tissue hyperplasia of balloon-expandable, biodegradable stents (BEBSs) with those of self-expandable metallic stents (SEMSs) in a rat urethral model.

Materials and Methods

A total of 20 rats were randomized into two groups. The BEBS group (n = 10) received a poly-l-lactic acid (PLLA) biodegradable stent. The SEMS group (n = 10) received a nitinol bare stent. All rats were killed eight weeks after stent placement. The degree of stent-induced tissue hyperplasia was assessed by comparing the results of retrograde urethrography and histologic examination between the two groups.

Results

Stent placement was technically successful in all rats. Two rats in the BEBS group were excluded due to procedure-related death. The mean luminal diameter of stented urethra on urethrograms was not significantly different at 4 and 8 weeks between the two groups. On histologic analysis, the percentage of granulation tissue area (p < 0.001) and the thickness of papillary projection (p < 0.001) were significantly higher in the BEBS group compared with the SEMS group. The inflammatory cell infiltration showed a clear tendency to significance (p = 0.050). There were no statistical differences in the number of epithelial layers and the thickness of submucosal fibrosis between the two groups.

Conclusion

Formation of stent-induced tissue hyperplasia was significantly evident in the rat urethra with similar degrees between the BEBS and the SEMS. The BEBS was associated with a thicker papillary projection and larger granulation tissue area resulting from higher inflammation compared with the SEMS.

Keywords

Self-expandable metallic stent Biodegradable stent Tissue hyperplasia Poly-l-lactic acid 

Notes

Funding

This study was supported by Fund of Biomedical Research Institute (CUH2018-0022), Chonbuk National University Hospital

Compliance with Ethical Standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical Approval

All applicable international, national, and/or institutional guidelines for the care and use of animals were followed.

Informed Consent

For this type of study, informed consent is not required.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE) 2019

Authors and Affiliations

  1. 1.Department of Radiology and Research Institute of RadiologyUniversity of Ulsan College of MedicineSeoulRepublic of Korea
  2. 2.Department of Biomedical Engineering Research CenterAsan Medical Center, University of Ulsan College of MedicineSeoulRepublic of Korea
  3. 3.Department of Radiological ScienceKangwon National UniversitySamcheok-SiRepublic of Korea
  4. 4.Division of Gastroenterology, Department of Internal Medicine, and Research Institute of Clinical MedicineChonbuk National UniversityJeonjuRepublic of Korea
  5. 5.Department of Radiology, and Research Institute of Clinical Medicine of Chonbuk National University-Biomedical Research InstituteChonbuk National UniversityJeonjuRepublic of Korea

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