Development of Repeatable Microcatheter Access Port for Intra-arterial Therapy of Liver Cancer
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To develop an implantable port in which a microcatheter can be inserted for a combination therapy of repeated transarterial chemoembolization (TACE) and hepatic arterial infusion chemotherapy (HAIC) for advanced liver cancer.
Materials and Methods
The design of a currently used implantable port was modified. A funnel part was constructed in the port. The septum was punctured by a 20-gauge indwelling needle, and 2.0-Fr non-tapered microcatheter was inserted into the port. In the in vitro studies, the advance of a microcatheter out of the funnel part was evaluated via seven different septum puncture sites. A 5-Fr indwelling catheter connected to the port was placed in a vascular model, and a microcatheter catheterization was evaluated. In an in vivo study, the port–catheter system was implanted in the hepatic artery in a pig. A microcatheter was percutaneously inserted through the port into the hepatic arterial branches, and embolization was performed.
In the in vitro studies, the microcatheter was smoothly advanced out of the port and catheterizations into the hepatic arteries were successful via all septum puncture sites. In the in vivo study, repeated selective embolization through the port was successfully conducted on 7, 14 and 21 days after the implantation.
The developed implantable port can be used for repeated catheter insertion into the hepatic artery. The combination of repeated TACE and HAIC could be possible using this device.
KeywordsTransarterial chemoembolization Hepatic arterial infusion chemotherapy Implantable port
We thank Dr. Shunsuke Shimamura and Dr. Terumasa Shimada, Veterinary Medical Center, Osaka Prefecture University, for support in this animal study. We thank Ms. Marian Pahud for advice in submitting this article. This work was supported by Grant-in-Aid for Scientific Research (C), 15K09967.
Compliance with Ethical Standards
Conflict of interest
All authors have no conflicts of interest and financial disclosures to declare.
All applicable institutional and national guidelines for the care and use of animals were followed.
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