Cancer Immunotherapy: A Simple Guide for Interventional Radiologists of New Therapeutic Approaches

  • A. DigkliaEmail author
  • R. Duran
  • K. Homicsko
  • L. E. Kandalaft
  • A. Hocquelet
  • A. Orcurto
  • G. Coukos
  • A. Denys


The therapeutic options in the treatment of cancer therapy have been recently significantly increased with systemic immune-targeted therapies. Novel immunotherapy approaches based on immune checkpoint blockade or engineered cytotoxic T lymphocytes have reached late-stage clinical development, with highly encouraging results. The success of cancer immunotherapy has generated a tremendous interest in further developing and exploring these strategies in combination with other approaches such as radiotherapy and local ablative therapies in oncology. The goal of this review is to discuss current approaches in immunotherapy and provide simple and constructive explanations on their mechanisms of action as well as certain more common and serious toxicities.


Cancer Immunotherapy Interventional radiology 


Compliance with Ethical Standards

Conflict of interest

G. Coukos reports grants from Bristol‐Myers‐Squibb, Roche, the National Institutes of Health, Celgene and Boehringer–Ingelheim; personal fees from Roche and Genentech; and support for clinical trials from Bristol‐Myers‐Squibb, Merck and Roche. A. Denys is a contracted consultant for BTG, Farnham, UK. Patent WO 2012/073188 A1 was issued and licensed to BTG by A. Denys. K. Homicsko reports grant from Roche and is a consultant/advisory board member for BMS, Merck Serono, Roche and AMGEN. L.E. Kandalaft reports that she is a consultant/advisory board member of Geneos. A. Digklia and A. Hocquelet have nothing to disclose. R. Duran reports grant from BTG.

Ethical Approval

This article does not contain any studies with human participants or animals performed by any of the authors.


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE) 2018

Authors and Affiliations

  1. 1.Department of OncologyCHUVLausanneSwitzerland
  2. 2.Department of Oncology, Ludwig Institute for Cancer ResearchUniversity of LausanneLausanneSwitzerland
  3. 3.Department of Radiology and Interventional RadiologyLausanne University HospitalLausanneSwitzerland
  4. 4.University of LausanneLausanneSwitzerland

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