CardioVascular and Interventional Radiology

, Volume 41, Issue 3, pp 363–365 | Cite as

DAWN: Another Boost for Endovascular Thrombectomy in Patients with Acute Ischemic Stroke


Klaus A. Hausegger, CVIR Editor-in-Chief

Raman Uberoi, CVIR Deputy Editor

Very recently, the results of the DAWN trial were published [1]. The results of this prospective randomized trial are of major interest for two reasons: first, it has been shown that patients with an occlusion of the internal carotid artery or proximal middle cerebral artery may benefit from endovascular thrombectomy with an extended time window of up to 24 h after the onset of stroke symptoms. The previously published positive randomized trials limited the time window to a maximum of 12 h, with no clear indication as to whether patients presenting with a wake-up stroke or an unknown time window should be treated at all [2, 3, 4, 5, 6, 7, 8].

Second, a mismatch between the clinical stroke presentation and infarct volume was one major inclusion criterion. The infarct volume was determined either by MR diffusion-weighted imaging (DWI) or CT perfusion (CTP), and an infarct volume of 51 ml maximum was accepted. In...


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