CardioVascular and Interventional Radiology

, Volume 41, Issue 4, pp 603–609 | Cite as

Acute Biliary Obstruction After Gastroduodenal Covered Self-Expanding Metallic Stent Placement in Patients with Previous Biliary Stent Placement for Periampullary Cancer: Frequency and Protective Factors

  • Kun Yung Kim
  • Jiaywei Tsauo
  • Pyeong Hwa Kim
  • Jung-Hoon Park
  • Zhe Wang
  • Min Tae Kim
  • Ho-Young SongEmail author
Clinical Investigation



We aimed to evaluate the frequency and protective factors of acute biliary obstruction in patients with biliary stent placement followed by gastroduodenal covered self-expandable metallic stent (SEMS) placement owing to progression of periampullary cancer.

Materials and Methods

We retrospectively reviewed 58 patients. Total bilirubin and alkaline phosphatase (ALP) levels before and after gastroduodenal covered SEMS placement were evaluated. The incidence of acute biliary obstruction correlated to age, sex, biliary stent length and type, and longitudinal and axial locations of the lower end of the biliary stent was evaluated.


Postprocedural total bilirubin and ALP levels were significantly higher than preprocedural levels (2.30 ± 2.53 vs. 1.53 ± 1.48 mg/dL; P = 0.008, 331.0 ± 248.8 vs. 258.4 ± 195.2 IU/L; P = 0.008, respectively). The increase in bilirubin levels was not statistically significant in female patients or patients with a biliary stent length ≥ 6 cm or longitudinal location of the lower end of the biliary stent distal to the lower end of the gastroduodenal stent (P > 0.05). Seven patients (12.1%) developed acute biliary obstruction. No patients with the lower end of the biliary stent located distal to the lower end of the gastroduodenal stent developed acute biliary obstruction (P = 0.012).


The incidence of acute biliary obstruction was 12.1% among patients with biliary stent placement followed by gastroduodenal covered SEMS placement. Longitudinal location of the lower end of the biliary stent distal to the lower end of the gastroduodenal stent was a protective factor.


Duodenum Stent Bile ducts 



This study was supported by a grant from the Korean Health Technology R&D Project, Ministry of Health and Welfare, Republic of Korea (Grant Number: HI15C0484 to H.Y.S.).

Compliance with Ethical Standards

Conflict of interest

None of the authors has any potential financial conflict of interest related to this manuscript.

Ethical Approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.


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Copyright information

© Springer Science+Business Media, LLC and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE) 2017

Authors and Affiliations

  • Kun Yung Kim
    • 1
  • Jiaywei Tsauo
    • 1
  • Pyeong Hwa Kim
    • 1
  • Jung-Hoon Park
    • 1
    • 2
  • Zhe Wang
    • 1
    • 3
  • Min Tae Kim
    • 1
  • Ho-Young Song
    • 1
    Email author
  1. 1.Department of Radiology, Research Institute of Radiology, Asan Medical CenterUniversity of Ulsan College of MedicineSeoulRepublic of Korea
  2. 2.Department of Biomedical Engineering Research Center, Asan Medical CenterUniversity of Ulsan College of MedicineSeoulRepublic of Korea
  3. 3.Department of RadiologyTianjin Medical University General HospitalTianjinPeople’s Republic of China

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