CardioVascular and Interventional Radiology

, Volume 39, Issue 10, pp 1372–1378 | Cite as

Comparative Study Using 100–300 Versus 300–500 μm Microspheres for Symptomatic Patients Due to Enlarged-BPH Prostates

  • Octavio Meneghelli GonçalvesEmail author
  • Francisco Cesar Carnevale
  • Airton Mota Moreira
  • Alberto Azoubel Antunes
  • Vanessa Cristina Rodrigues
  • Miguel Srougi
Clinical Investigation



The purpose of the study was to compare safety and efficacy outcomes following prostate artery embolization (PAE) for the treatment of lower urinary tract symptoms (LUTS) due to benign prostatic hyperplasia (BPH) with 100–300 versus 300–500 μm tris-acryl gelatin microspheres.

Materials and Methods

Patients were prospectively treated between August 2011 and June 2013 to receive PAE with 100–300 μm (group A) or 300–500 μm (group B) tris-acryl gelatin microspheres. Patients were followed for a minimum of 12 months and were assessed for changes in International Prostate Symptom Score (IPSS), quality of life (QoL) index, prostate volume determined by magnetic resonance imaging, serum prostate specific antigen (PSA), and maximum urine flow rate (Qmax), as well as any treatment-related adverse events.


Fifteen patients were included in each group, and PAE was technically successful in all cases. Both groups experienced significant improvement in mean IPSS, QoL, prostate volume, PSA, and Qmax (p < 0.05 for all). The differences observed between the two groups included a marginally insignificant more adverse events (p = 0.066) and greater mean serum PSA reduction at 3 months of follow-up (p = 0.056) in group A.


Both 100–300 and 300–500 μm microspheres are safe and effective embolic agents for PAE to treat LUTS-related to BPH. Although functional and imaging outcomes did not differ significantly following use of the two embolic sizes, the greater incidence of adverse events with 100–300 μm microspheres suggests that 300–500 μm embolic materials may be more appropriate.


Arterial intervention Embolization Embolotherapy Prostate 



Benign prostatic hyperplasia


Bladder outlet obstruction


International Prostate Symptom Score


Lower urinary tract symptoms


Magnetic resonance imaging


Maximum urinary flow rate


Polyvinyl alcohol


Prostate-specific antigen


Prostatic artery embolization


Quality of life index


Transurethral resection of the prostate



The authors thank Sardis Honoria Harward for her important collaboration.

Compliance with Ethical Standards

Conflict of Interest

The authors declare that they have no financial disclosure.

Ethical Approval

All procedures performed in this study were in accordance with the Ethical standards of the institutional and national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.


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Copyright information

© Springer Science+Business Media New York and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE) 2016

Authors and Affiliations

  • Octavio Meneghelli Gonçalves
    • 1
    Email author
  • Francisco Cesar Carnevale
    • 1
  • Airton Mota Moreira
    • 1
  • Alberto Azoubel Antunes
    • 2
  • Vanessa Cristina Rodrigues
    • 1
  • Miguel Srougi
    • 2
  1. 1.Interventional Radiology UnitUniversity of Sao Paulo Medical SchoolSao PauloBrazil
  2. 2.Division of UrologyUniversity of Sao Paulo Medical SchoolSao PauloBrazil

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