CardioVascular and Interventional Radiology

, Volume 39, Issue 10, pp 1420–1428 | Cite as

Treatment Outcome Following Transarterial Chemoembolization in Advanced Bone and Soft Tissue Sarcomas

  • Chunyu Jiang
  • Jianbo Wang
  • Yonggang Wang
  • Jungong Zhao
  • Yueqi Zhu
  • Xu Ma
  • Jia Zhou
  • Xuebing Yan
Clinical Investigation
First Online:
Received:
Accepted:

Abstract

Purpose

Transarterial chemoembolization (TACE) is used to treat unresectable bone and soft tissue sarcoma (STS) and as a pre-surgical adjuvant treatment. However, its efficiency for advanced STS is undetermined. This study evaluated TACE’s efficiency in treating advanced STS and prognostic factors for patient survival.

Materials and Methods

We enrolled 39 patients with unresectable STS who underwent TACE as an alternative treatment during 2010–2014, with overall survival (OS) as the primary end point. Cancer pain was evaluated by visual analogue scores (VAS) before and after TACE procedures. Factors that affect survival were evaluated by multivariate analyses (Cox proportional hazard model).

Results

Mean OS after TACE was 23.7 ± 2.1 months, with 1-year OS 71.5 %, 2-year OS 45.8 %, and 3-year OS 32.5 %. Lesion number and tumor stage were key predictors of survival. TACE was found to decrease cancer pain VAS and increase relapse interval. Size of polyvinyl alcohol (PVA) particle diameter (P = 0.03) and imaging response (P = 0.044) were also found to affect relapse interval.

Conclusion

TACE was an effective treatment for advanced STS, with a 32.5 % 3-year OS rate, and led to lower cancer pain VAS and longer relapse intervals than chemoinfusion only. Smaller PVA particles are preferable during the TACE procedure.

Keywords

Transarterial chemoembolization Bone sarcoma Soft tissue sarcoma Overall survival Prognosis 
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Notes

Acknowledgments

This work was partly funded by Key Disciplines Group Construction Project of Pudong Health Bureau of Shanghai (No. PWZxq2014-07), funding of Science and Technology Commission of Shanghai Municipality (No. 12ZR1422700) and Shen-Kang Hospital Development Center Project of Shanghai (No. SHDC12014902), and this work was also supported by National Natural Science Fundation of China (No. 81271683).

Compliance with Ethical Standards

Conflict of interest

We declare that we have no financial and personal relationships with people or organizations that can inappropriately influence our work; there is no professional or other personal interest of any nature or kind in any product, service and/or company that could be construed as influencing the position presented in, or the review of, the manuscript entitled.

Supplementary material

270_2016_1399_MOESM1_ESM.docx (25 kb)
Supplementary material 1 (DOCX 24 kb)

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Copyright information

© Springer Science+Business Media New York and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE) 2016

Authors and Affiliations

  1. 1.Department of RadiologyShanghai Jiaotong University Affiliated Sixth People’s HospitalShanghaiPeople’s Republic of China
  2. 2.Department of OncologyShanghai Jiaotong University Affiliated Sixth People’s HospitalShanghaiPeople’s Republic of China
  3. 3.Department of General SurgeryShanghai Jiaotong University Affiliated Sixth People’s HospitalShanghaiPeople’s Republic of China

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