Irreversible Electroporation of Prostate Cancer: Patient-Specific Pretreatment Simulation by Electric Field Measurement in a 3D Bioprinted Textured Prostate Cancer Model to Achieve Optimal Electroporation Parameters for Image-Guided Focal Ablation
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Irreversible electroporation (IRE) of localized prostate cancer (PCA) for curatively intended treatment is still considered experimental, though first study results confirm its high developmental potential as an organ- and function-preserving focal therapy. Current limitations thus far include exact calculation of the ablation field, congruence between tumor localization and extension of the ablation field, and organ confinement of the ablation field with sparing of structures/organs at risk. Van den Bos et al. , for example, described the ablation field as being two-to-three times larger than expected and extending beyond the prostatic capsule into the neurovascular bundle with the corresponding risks of stress incontinence and erectile dysfunction. Two important factors are discussed. For one thing, electric field configuration strongly depends on tissue heterogeneity and conductivity . The aging prostate with PCA is a very inhomogeneous tissue or organ (PCA, nodular...
KeywordsElectrical Impedance Tomography Irreversible Electroporation Electric Field Measurement Image Fusion Algorithm Electric Field Configuration
AngioDynamics Inc. (NY, USA) supports the current IRENE study [ClinicalTrials.gov: NCT01967407] by providing the NanoKnife electroporator device and technical maintenance. The authors declare that they have no conflict of interest.
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Conflict of Interest
The authors declare that they have no conflict of interest.
All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.
Informed consent was obtained from all individual participants included in the study.