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CardioVascular and Interventional Radiology

, Volume 38, Issue 6, pp 1532–1541 | Cite as

Transarterial Chemoembolization of Liver Metastases from Uveal Melanoma Using Irinotecan-Loaded Beads: Treatment Response and Complications

  • Ulrik CarlingEmail author
  • Eric J. Dorenberg
  • Sven-Petter Haugvik
  • Nils Andreas Eide
  • Dag Tallak Berntzen
  • Bjørn Edwin
  • Svein Dueland
  • Bård Røsok
Clinical Investigation

Abstract

Purpose

The purpose of this study was to evaluate treatment response and complications of transarterial chemoembolization using drug-eluting beads loaded with irinotecan (DEBIRI) in patients with liver metastases from uveal melanoma (UM).

Materials and Methods

Patients treated with DEBIRI (n = 14) were retrospectively analyzed regarding overall survival, compared to patients (n = 14) treated with intravenous dacarbazine (DTIC). Median overall survival was calculated from time of diagnosis of metastatic disease (OS1) and start of treatment (OS2). Radiological response for DEBIRI was assessed according to RECIST 1.1 on contrast-enhanced computed tomography (CT), obtained 1.5 months (range 1.2–3.7) post treatment. Major complications of DEBIRI were defined according to the Society of Interventional Radiology classification for complications by outcome.

Results

In the DEBIRI group, OS1 was 14.8 months (range 3.9–47.5), and OS2 was 9.4 months (range 1.7–39). Further, 11/13 (84.6 %) of these patients had progressive disease on first follow-up CT and new lesions were seen in nine. There were 12 major complications in nine patients, possibly including one case of mortality due to disseminated intravascular coagulation (DIC).

Conclusion

For patients with liver metastases from UM, the effect on overall survival of DEBIRI alone is questionable. Compared to previous reports, the response rate of DEBIRI was poor, with new liver lesions observed in the majority of patients. Major complications possibly included one case of DIC.

Keywords

Transarterial chemoembolization Uveal melanoma Liver metastases DEBIRI Irinotecan Drug-eluting beads 

Notes

Conflict of Interest

All authors declare that they have no conflicts of interest.

Statement of Informed Consent

Statement of informed consent does not apply to this article.

Statement of Human and Animal Rights

Statement of human and animal rights does not apply to this article.

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Copyright information

© Springer Science+Business Media New York and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE) 2015

Authors and Affiliations

  • Ulrik Carling
    • 1
    Email author
  • Eric J. Dorenberg
    • 1
  • Sven-Petter Haugvik
    • 2
  • Nils Andreas Eide
    • 3
  • Dag Tallak Berntzen
    • 1
  • Bjørn Edwin
    • 4
  • Svein Dueland
    • 5
  • Bård Røsok
    • 2
  1. 1.Department of Radiology and Nuclear MedicineOslo University HospitalOsloNorway
  2. 2.Department of Hepato-Pancreato-Biliary SurgeryOslo University HospitalOsloNorway
  3. 3.Department of OphthalmologyOslo University HospitalOsloNorway
  4. 4.The Intervention CentreOslo University HospitalOsloNorway
  5. 5.Department of OncologyOslo University HospitalOsloNorway

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