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CardioVascular and Interventional Radiology

, Volume 37, Issue 3, pp 586–591 | Cite as

Minimally Invasive Ablation Treatment for Locally Advanced Pancreatic Adenocarcinoma

  • Michele Rossi
  • Gianluigi Orgera
  • Adam Hatzidakis
  • Miltiadis Krokidis
Review

Abstract

Pancreatic adenocarcinoma is an aggressive tumour with an extremely poor prognosis, which has not changed significantly during the last 30 years. Prolonged survival is achieved only by R0 resection with macroscopic tumour clearance. However, the majority of the cases are considered inoperable at diagnosis due to local spread or presence of metastatic disease. Chemoradiotherapy is not tolerated by all patients and still fails to prolong survival significantly; neoadjuvant treatment also has limited results on pain control or tumour downstaging. In recent years, there has been a growing interest in the use of ablation therapy for the treatment of nonresectable tumours in various organs. Ablation techniques are based on direct application of chemical, thermal, or electrical energy to a tumour, which leads to cellular necrosis. With ablation, tumour cytoreduction, local control, and relief from symptoms are obtained in the majority of the patients. Inoperable cases of pancreatic adenocarcinoma have been treated by various ablation techniques in the last few years with promising results. The purpose of this review is to present the current status of local ablative therapies in the treatment of pancreatic adenocarcinoma and to investigate on the efficiency and the future trends.

Keywords

Pancreatic cancer Ablation Loco-regional treatment Interventional oncology 

Notes

Conflict of interest

All authors have no conflict of interest to disclose.

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Copyright information

© Springer Science+Business Media New York and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE) 2013

Authors and Affiliations

  • Michele Rossi
    • 1
  • Gianluigi Orgera
    • 1
  • Adam Hatzidakis
    • 2
  • Miltiadis Krokidis
    • 3
  1. 1.Unit of Interventional RadiologyS. Andrea University Hospital “Sapienza”RomeItaly
  2. 2.Department of Radiology, Medical School of CreteUniversity Hospital of HeraklionHeraklionGreece
  3. 3.Department of RadiologyCambridge University Hospitals NHS TrustCambridgeUK

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