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CardioVascular and Interventional Radiology

, Volume 36, Issue 2, pp 292–301 | Cite as

MR-Guided High-Intensity Focused Ultrasound Ablation of Breast Cancer with a Dedicated Breast Platform

  • Laura G. Merckel
  • Lambertus W. Bartels
  • Max O. Köhler
  • H. J. G. Desirée van den Bongard
  • Roel Deckers
  • Willem P. Th. M. Mali
  • Christoph A. Binkert
  • Chrit T. Moonen
  • Kenneth G. A. Gilhuijs
  • Maurice A. A. J. van den BoschEmail author
Review

Abstract

Optimizing the treatment of breast cancer remains a major topic of interest. In current clinical practice, breast-conserving therapy is the standard of care for patients with localized breast cancer. Technological developments have fueled interest in less invasive breast cancer treatment. Magnetic resonance-guided high-intensity focused ultrasound (MR-HIFU) is a completely noninvasive ablation technique. Focused beams of ultrasound are used for ablation of the target lesion without disrupting the skin and subcutaneous tissues in the beam path. MRI is an excellent imaging method for tumor targeting, treatment monitoring, and evaluation of treatment results. The combination of HIFU and MR imaging offers an opportunity for image-guided ablation of breast cancer. Previous studies of MR-HIFU in breast cancer patients reported a limited efficacy, which hampered the clinical translation of this technique. These prior studies were performed without an MR-HIFU system specifically developed for breast cancer treatment. In this article, a novel and dedicated MR-HIFU breast platform is presented. This system has been designed for safe and effective MR-HIFU ablation of breast cancer. Furthermore, both clinical and technical challenges are discussed, which have to be solved before MR-HIFU ablation of breast cancer can be implemented in routine clinical practice.

Keywords

Breast Interventional oncology High-intensity focused ultrasound Cancer 

Notes

Acknowledgments

This research was supported by the Center for Translational Molecular Medicine (VOLTA, Work Package 3).

Conflict of interest

This research was performed in collaboration with Philips Healthcare. Max O. Köhler is currently employed in this company. The other authors declare that they have no conflict of interest.

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Copyright information

© Springer Science+Business Media New York and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE) 2012

Authors and Affiliations

  • Laura G. Merckel
    • 1
  • Lambertus W. Bartels
    • 2
  • Max O. Köhler
    • 3
  • H. J. G. Desirée van den Bongard
    • 4
  • Roel Deckers
    • 2
  • Willem P. Th. M. Mali
    • 1
  • Christoph A. Binkert
    • 5
  • Chrit T. Moonen
    • 2
  • Kenneth G. A. Gilhuijs
    • 1
    • 2
  • Maurice A. A. J. van den Bosch
    • 1
    Email author
  1. 1.Department of RadiologyUniversity Medical Center UtrechtCX UtrechtThe Netherlands
  2. 2.Image Sciences InstituteUniversity Medical Center UtrechtUtrechtThe Netherlands
  3. 3.Philips HealthcareVantaaFinland
  4. 4.Department of RadiotherapyUniversity Medical Center UtrechtUtrechtThe Netherlands
  5. 5.Department of RadiologyCantonal Hospital WinterthurWinterthurSwitzerland

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