CardioVascular and Interventional Radiology

, Volume 36, Issue 2, pp 353–361 | Cite as

Randomized Trial of the SMART Stent versus Balloon Angioplasty in Long Superficial Femoral Artery Lesions: The SUPER Study

  • Nicholas Chalmers
  • Paul T. Walker
  • Anna-Maria Belli
  • Anthony P. Thorpe
  • Paul S. Sidhu
  • Graham Robinson
  • Mariella van Ransbeeck
  • Steven A. Fearn
Clinical Investigation

Abstract

Purpose

To determine whether primary stenting reduces the rate of restenosis compared with balloon angioplasty alone in the endovascular treatment of long superficial femoral artery lesions; and to assess the effect of treatment on quality of life.

Methods

A total of 150 patients with superior femoral artery occlusion or severe stenosis of 5–22 cm length from 17 UK centers were randomized to either primary stenting with the SMART stent or balloon angioplasty (i.e., percutaneous transluminal angioplasty, PTA). Bailout stent placement was permitted in case of inadequate result from PTA. The primary end point was restenosis measured by duplex ultrasound at 1 year. Quality-of-life assessments were performed by the EuroQol (EQ)-5D questionnaire.

Results

Mean lesion length was 123.0 mm in the stent group and 116.8 mm in the PTA group. A total of 140 (93.3 %) of 150 had total occlusions. At 12 months’ follow-up, restenosis measured by Duplex ultrasound was not significantly different between the stent and PTA groups by intention-to-treat or as-treated analyses: 47.2 versus 43.5 % (p = 0.84) and 40.8 versus 46.7 % (p = 0.68), respectively. There were fewer target lesion revascularizations in patients randomized to stenting, but this did not reach statistical significance (12.5 vs. 20.8 %, p = 0.26). There was no difference in the rate of amputation. Patients in both groups reported improved quality of life.

Conclusion

Primary stenting of long lesions in predominantly occluded superficial femoral arteries does not reduce the rate of binary restenosis compared with balloon angioplasty and bailout stenting. Both treatment strategies conferred a meaningful and sustained improvement to the quality of life of patients with severe superficial femoral artery disease.

Keywords

Balloon angioplasty Long lesions Randomized trial SMART stent Superficial femoral artery 

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Copyright information

© Springer Science+Business Media New York and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE) 2012

Authors and Affiliations

  • Nicholas Chalmers
    • 1
  • Paul T. Walker
    • 2
  • Anna-Maria Belli
    • 3
  • Anthony P. Thorpe
    • 4
  • Paul S. Sidhu
    • 5
  • Graham Robinson
    • 6
  • Mariella van Ransbeeck
    • 7
  • Steven A. Fearn
    • 8
  1. 1.Department of RadiologyManchester Royal InfirmaryManchesterUK
  2. 2.Department of RadiologyJames Cook University HospitalMiddlesboroughUK
  3. 3.Department of RadiologySt. George’s Healthcare NHS TrustLondonUK
  4. 4.Department of RadiologyAberdeen Royal InfirmaryAberdeenScotland, UK
  5. 5.Department of RadiologyKing’s College HospitalLondonUK
  6. 6.Department of RadiologyHull Royal InfirmaryKingston upon HullUK
  7. 7.CordisJohnson & Johnson Medical NV/SAWaterlooBelgium
  8. 8.CordisJohnson & Johnson Medical Ltd.WokinghamUK

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