CardioVascular and Interventional Radiology

, Volume 36, Issue 4, pp 1155–1160 | Cite as

Radioembolization of the Spleen: A Revisited Approach for the Treatment of Malignant Lymphomatous Splenomegaly

  • Kristoff Muylle
  • Jasmine Nguyen
  • Alexandre de Wind
  • Nathalie Meuleman
  • Philippe Delatte
  • Bruno Vanderlinden
  • Martine Roelandts
  • Anja Van der Stappen
  • Dominique Bron
  • Patrick Flamen
Case Report

Abstract

Intraarterial administration of 90Y microspheres to the spleen in patients with malignant lymphoma was mentioned once in the literature in 1973. This case study illustrates the potential indication of selective internal radiotherapy in a heavily pretreated patient with highly refractory disease with a marginal zone lymphoma in leukemic phase and symptomatic splenomegaly. We describe the clinical course of disease; the biological and clinical response to the treatment after radioembolization; and simulation and dosimetry by multimodal imaging via single-photon emission computed tomography and computed tomography. The advantages of radioembolization for the management of lymphomatous splenomegaly are discussed.

Keywords

Lymphoma Radioembolization Spleen Splenomegaly 

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Copyright information

© Springer Science+Business Media, LLC and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE) 2012

Authors and Affiliations

  • Kristoff Muylle
    • 1
    • 2
  • Jasmine Nguyen
    • 3
  • Alexandre de Wind
    • 4
  • Nathalie Meuleman
    • 3
  • Philippe Delatte
    • 5
  • Bruno Vanderlinden
    • 6
  • Martine Roelandts
    • 7
  • Anja Van der Stappen
    • 8
  • Dominique Bron
    • 3
  • Patrick Flamen
    • 1
  1. 1.Department of Nuclear MedicineJules Bordet Institute, ULBBrusselsBelgium
  2. 2.Faculty of MedicineVUBBrusselsBelgium
  3. 3.Department of HaematologyJules Bordet Institute, ULBBrusselsBelgium
  4. 4.Department of Anatomo-PathologyJules Bordet Institute, ULBBrusselsBelgium
  5. 5.Department of Interventional RadiologyUMC Sint-PieterBrusselsBelgium
  6. 6.Department of RadiophysicsJules Bordet Institute, ULBBrusselsBelgium
  7. 7.Department of RadiotherapyJules Bordet Institute, ULBBrusselsBelgium
  8. 8.Department of RadiologyJules Bordet Institute, ULBBrusselsBelgium

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