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CardioVascular and Interventional Radiology

, Volume 36, Issue 2, pp 545–548 | Cite as

Intra-arterial Autologous Bone Marrow Cell Transplantation in a Patient with Upper-extremity Critical Limb Ischemia

  • Juraj Madaric
  • Andrej Klepanec
  • Martin Mistrik
  • Cestmir Altaner
  • Ivan Vulev
Case Report

Abstract

Induction of therapeutic angiogenesis by autologous bone marrow mononuclear cell transplantation has been identified as a potential new option in patients with advanced lower-limb ischemia. There is little evidence of the benefit of intra-arterial cell application in upper-limb critical ischemia. We describe a patient with upper-extremity critical limb ischemia with digital gangrene resulting from hypothenar hammer syndrome successfully treated by intra-arterial autologous bone marrow mononuclear cell transplantation.

Keywords

Critical limb ischemia Hypothenar hammer syndrome Intra-arterial administration Therapeutic angiogenesis Upper extremity 

Notes

Conflict of interest

The authors declare that they have no conflict of interest.

References

  1. 1.
    Tateishi-Yuyama E, Matsubara H, Murohara T et al (2002) Therapeutic angiogenesis for patients with limb ischaemia by autologous transplantation of bone-marrow cells: a pilot study and a randomised controlled trial. Lancet 360:427–435PubMedCrossRefGoogle Scholar
  2. 2.
    Chochola M, Pytlík R, Kobylka P et al (2008) Autologous intra-arterial infusion of bone marrow mononuclear cells in patients with critical limb ischemia. Int Angiol 27:281–290PubMedGoogle Scholar
  3. 3.
    Amann B, Luedemann C, Ratei R, Schmidt-Lucke JA (2009) Autologous bone marrow cell transplantation increases leg perfusion and reduces amputations in patients with advanced critical limb ischemia due to peripheral artery disease. Cell Transpl 18:371–380CrossRefGoogle Scholar
  4. 4.
    Comerota AJ, Lin A, Douville J, Burchardt ER (2010) Upper extremity ischemia treated with tissue repair cells from adult bone marrow. J Vasc Surg 52:723–729PubMedCrossRefGoogle Scholar
  5. 5.
    Koshikawa M, Shimodaira S, Yoshioka T et al (2006) Therapeutic angiogenesis by bone marrow implantation for critical hand ischemia in patients with peripheral arterial disease: a pilot study. Curr Med Res Opin 22:793–798PubMedCrossRefGoogle Scholar
  6. 6.
    Madaric J, Klepanec A, Mistrik M et al (2011) Autologous bone marrow cells transplantation in patients with advanced critical limb ischemia: no difference in intra-arterial and intramuscular application. JACC 57:E1473CrossRefGoogle Scholar
  7. 7.
    Chang BB, Roddy SP, Darling RC III et al (2003) Upper extremity bypass grafting for limb salvage in end-stage renal failure. J Vasc Surg 38:1313–1315PubMedCrossRefGoogle Scholar
  8. 8.
    Procházka V, Gumulec J, Jalůvka F et al (2010) Cell therapy, a new standard in management of chronic critical limb ischemia and foot ulcer. Cell Transpl 19:1413–1424CrossRefGoogle Scholar
  9. 9.
    Lara-Hernandez R, Lozano-Vilardell P, Blanes P et al (2010) Safety and efficacy of therapeutic angiogenesis as a novel treatment in patients with critical limb ischemia. Ann Vasc Surg 24:287–294PubMedCrossRefGoogle Scholar
  10. 10.
    Miyamoto K, Nishigami K, Nagaya N et al (2006) Unblinded pilot study of autologous transplantation of bone marrow mononuclear cells in patients with thromboangiitis obliterans. Circulation 114:2679–2684PubMedCrossRefGoogle Scholar
  11. 11.
    Bartsch T, Brehm M, Zeus T et al (2007) Transplantation of autologous mononuclear bone marrow stem cells in patients with peripheral arterial disease (the TAM-PAD study). Clin Res Cardiol 96:891–899PubMedCrossRefGoogle Scholar
  12. 12.
    Zhou B, Poon MC, Pu WT, Han ZC (2007) Therapeutic neovascularisation for peripheral arterial disease: advances and perspectives. Histol Histopathol 22:677–686PubMedGoogle Scholar
  13. 13.
    Sprengers RW, Lips DJ, Moll FL, Verhaar MC (2008) Progenitor cell therapy in patients with critical limb ischemia without surgical options. Ann Surg 247:411–420PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE) 2012

Authors and Affiliations

  • Juraj Madaric
    • 1
  • Andrej Klepanec
    • 2
  • Martin Mistrik
    • 3
  • Cestmir Altaner
    • 4
  • Ivan Vulev
    • 2
  1. 1.Department of Cardiology and AngiologyNational Institute of Cardiovascular Diseases (NUSCH) and Slovak Medical UniversityBratislavaSlovakia
  2. 2.Department of Diagnostic and Interventional RadiologyNational Institute of Cardiovascular DiseasesBratislavaSlovakia
  3. 3.Clinic of Hematology and Transfusiology, Faculty HospitalBratislavaSlovakia
  4. 4.Institute of Experimental OncologySlovak Academy of ScienceBratislavaSlovakia

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