CardioVascular and Interventional Radiology

, Volume 35, Issue 6, pp 1531–1534

Irreversible Electroporation for Focal Ablation at the Porta Hepatis

  • Veeru Kasivisvanathan
  • Ankur Thapar
  • Youssof Oskrochi
  • John Picard
  • Edward L. S. Leen
Case Report


Patients with chemotherapy-refractory liver metastases who are not candidates for surgery may be treated with focal ablation techniques with established survival benefits. Irreversible electroporation is the newest of these and has the putative advantages of a nonthermal action, preventing damage to adjacent biliary structures and bowel. This report describes the use of irreversible electroporation in a 61-year-old man with a solitary chemoresistant liver metastasis unsuitable for radiofrequency ablation as a result of its proximity to the porta hepatis. At 3 months, tumor size was decreased on computed tomography from 28 × 19 to 20 × 17 mm, representing stable disease according to the response evaluation criteria in solid tumors. This corresponded to a decrease in tumor volume size from 5.25 to 3.16 cm3. There were no early or late complications. Chemoresistant liver metastases in the proximity of the porta hepatis that are considered to be too high a risk for conventional surgery or thermal ablation may be considered for treatment by the novel ablation technique of irreversible electroporation.


Ablation Irreversible electroporation Liver Metastasis Tumor Ultrasound 

Supplementary material

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Supplementary material 1 (TIFF 1846 kb)
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Supplementary material 2 (TIFF 1646 kb)


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Copyright information

© Springer Science+Business Media, LLC and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE) 2012

Authors and Affiliations

  • Veeru Kasivisvanathan
    • 1
    • 2
    • 5
  • Ankur Thapar
    • 2
  • Youssof Oskrochi
    • 2
  • John Picard
    • 3
  • Edward L. S. Leen
    • 1
    • 4
  1. 1.Department of RadiologyImperial College LondonLondonUK
  2. 2.Department of Surgery and CancerImperial College LondonLondonUK
  3. 3.Department of AnaesthesiaImperial College Healthcare NHS TrustLondonUK
  4. 4.Department of Experimental MedicineImperial College LondonLondonUK
  5. 5.Charing Cross HospitalLondonUK

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