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CardioVascular and Interventional Radiology

, Volume 35, Issue 5, pp 1102–1108 | Cite as

Serum Gamma-Glutamyl-Transferase Independently Predicts Outcome After Transarterial Chemoembolization of Hepatocellular Carcinoma: External Validation

  • Boris Guiu
  • Frédéric Deschamps
  • Mathieu Boulin
  • Valérie Boige
  • David Malka
  • Michel Ducreux
  • Patrick Hillon
  • Thierry de Baère
Clinical Investigation

Abstract

Purpose

An Asian study showed that gamma glutamyl transpeptidase (GGT) can predict survival after transarterial chemoembolization (TACE) of hepatocellular carcinoma (HCC). This study was designed to validate in a European population this biomarker as an independent predictor of outcome after TACE of HCC and to determine a threshold value for clinical use.

Methods

In 88 consecutive patients treated by TACE for HCC, the optimal threshold for GGT serum level was determined by a ROC analysis. Endpoints were time-to-treatment failure (TTTF) and overall survival (OS). All multivariate models were internally validated using bootstrapping (90 replications).

Results

Median follow-up lasted 373 days, and median overall survival was 748 days. The optimal threshold for GGT was 165 U/L (sensitivity: 89.3%; specificity: 56.7%; area under the ROC curve: 0.7515). Median TTTF was shorter when GGT was ≥165 U/L (281 days vs. 850 days; P < 0.001). GGT ≥165 U/L (hazard ratio (HR) = 2.06; P = 0.02), WHO PS of 2 (HR = 5.4; P = 0.002), and tumor size (HR = 1.12; P = 0.014) were independently associated with shorter TTTF. Median OS was shorter when GGT was ≥165 U/L (508 days vs. not reached; P < 0.001). GGT ≥ 165 U/L (HR = 3.05; P = 0.029), WHO PS of 2 (HR = 12.95; P < 0.001), alfa-fetoprotein (HR = 2.9; P = 0.01), and tumor size (HR = 1.096; P = 0.013) were independently associated with shorter OS. The results were confirmed by bootstrapping.

Conclusions

Our results provide in a European population the external validation of GGT as an independent predictor of outcome after TACE of HCC. A serum level of GGT ≥ 165 U/L is independently associated with both shorter TTTF and OS.

Keywords

Liver cancer Cirrhosis Predictor Survival Chemoembolization 

Notes

Acknowledgments

The authors thank Philip Bastable for revising the English.

Conflict of interest

Boris Guiu, Frederic Deschamps, Mathieu Boulin, Valérie Boige, David Malka, Michel Ducreux, Patrick Hillon, and Thierry De Baère have no conflicts of interest to declare regarding this study.

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Copyright information

© Springer Science+Business Media, LLC and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE) 2011

Authors and Affiliations

  • Boris Guiu
    • 1
    • 2
    • 3
  • Frédéric Deschamps
    • 1
  • Mathieu Boulin
    • 3
  • Valérie Boige
    • 4
  • David Malka
    • 4
  • Michel Ducreux
    • 4
  • Patrick Hillon
    • 3
  • Thierry de Baère
    • 1
  1. 1.Department of Interventional RadiologyInstitut Gustave RoussyVillejuifFrance
  2. 2.Department of RadiologyUniversity HospitalDijonFrance
  3. 3.INSERM U866University HospitalDijonFrance
  4. 4.Department of Digestive OncologyInstitut Gustave RoussyVillejuifFrance

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