CardioVascular and Interventional Radiology

, Volume 34, Issue 6, pp 1123–1136 | Cite as

Quality Improvement Guidelines for Percutaneous Catheter-Directed Intra-Arterial Thrombolysis and Mechanical Thrombectomy for Acute Lower-Limb Ischemia

  • Dimitris KarnabatidisEmail author
  • Stavros Spiliopoulos
  • Dimitrios Tsetis
  • Dimitris Siablis
CIRSE Standards of Practice Guidelines


Thrombolytic therapy has been an established and effective treatment for acute limb ischemia for years [1, 2, 3]. The treatment options for this life-threatening condition are “open” surgery, percutaneous endovascular treatment, and intravenous (i.v.) systemic thrombolysis. Current percutaneous treatment includes catheter-mediated infusion of fibrinolytic agents (pharmacological thrombolysis), pharmacomechanical thrombolysis, catheter-mediated thrombus aspiration, mechanical thrombectomy, and a combination of the above [4, 5, 6, 7, 8, 9, 10]. This study was designed to quality assurance guidelines concerning the treatment of acute and subacute arterial limb ischemia, with the use of percutaneous catheter-directed pharmacological thrombolysis and mechanical thrombectomy or a combination of both.

Thrombolytic Agents

Thrombolytic agents, also named fibrinolytic because fibrin is the basic constituent of thrombus, are exogenous substances that enhance the natural endogenous...


Bivalirudin Thrombolytic Agent Critical Limb Ischemia Mechanical Thrombectomy Amputation Rate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Conflict of interest

The authors declare that they have no conflict of interest.


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Copyright information

© Springer Science+Business Media, LLC and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE) 2011

Authors and Affiliations

  • Dimitris Karnabatidis
    • 1
    • 3
    Email author
  • Stavros Spiliopoulos
    • 1
  • Dimitrios Tsetis
    • 2
  • Dimitris Siablis
    • 1
  1. 1.Department of RadiologyPatras University Hospital, School of MedicineRionGreece
  2. 2.Department of Interventional RadiologyHeraklion University Hospital, School of MedicineHeraklionGreece
  3. 3.Department of Diagnostic and Interventional Radiology, Angiography SuiteRion University HospitalRionGreece

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