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CardioVascular and Interventional Radiology

, Volume 35, Issue 5, pp 1154–1162 | Cite as

Placement of Endovascular Stent across the Branching Arteries: Long-term Serial Evaluation of Stent-tissue Responses Overlying the Arterial Orifices in an Experimental Study

  • Young Il Kim
  • Jin Wook ChungEmail author
  • Hyun Beom Kim
  • Jae Hyung Park
  • Jeong Wook Seo
  • Hyo-Cheol Kim
  • Hwan Jun Jae
  • Whal Lee
Laboratory Investigation

Abstract

Purpose

This study was designed to investigate the effects of stenting across the branching arteries on the patency and stent-tissue responses over the branching arterial orifices.

Methods

Thirteen dogs were observed after placing aortic stents across the celiac arteries (CA), superior mesenteric arteries (SMA), and renal arteries (RA). The animals were grouped according to stent types: large-cell group (n = 6) and small-cell group (n = 7). Angiography was performed to evaluate the branching artery patency at 2, 6, and 12 months after stent insertion, and the stent-tissue responses covering the orifices were evaluated on histopathologic examination.

Results

All branching arteries were patent on follow-up angiography; however, three patterns of stent-tissue responses over the orifices were observed: neointimal layering, bridging septa, and papillary hyperplasia. Although neointimal layering and bridging septa were evenly observed, severe papillary hyperplasia was more frequent at SMA and CA than RA. Four RA showed less than 50% ostial patency, and localized infarct was observed in six kidneys (24%). The ostial patency tended to decrease with small-cell stent during the follow-up period.

Conclusions

Various stent-tissue responses over the branching artery orifices are induced by the aortic stent covering the branching arteries and may not be easily detected by conventional angiography. Subclinical renal infarct also may occur despite patent renal angiography.

Keywords

Endovascular procedure Intimal hyperplasia Branching arteries Orifice Animal experiment 

Notes

Conflict of interest

The authors declare that they have no conflict of interest.

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Copyright information

© Springer Science+Business Media, LLC and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE) 2011

Authors and Affiliations

  • Young Il Kim
    • 1
  • Jin Wook Chung
    • 1
    Email author
  • Hyun Beom Kim
    • 2
  • Jae Hyung Park
    • 1
  • Jeong Wook Seo
    • 3
  • Hyo-Cheol Kim
    • 1
  • Hwan Jun Jae
    • 1
  • Whal Lee
    • 1
  1. 1.Department of RadiologySeoul National University College of MedicineJongno-guKorea
  2. 2.Department of Radiology and Center for Liver Cancer, Research Institute and HospitalNational Cancer Center of KoreaGoyangKorea
  3. 3.Department of PathologySeoul National University College of MedicineSeoulKorea

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