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CardioVascular and Interventional Radiology

, Volume 35, Issue 2, pp 351–358 | Cite as

Intraluminal Radioactive Stent Compared with Covered Stent Alone for the Treatment of Malignant Esophageal Stricture

  • Wang Zhongmin
  • Huang Xunbo
  • Cao Jun
  • Huang Gang
  • Chen Kemin
  • Liu Yu
  • Liu FenjuEmail author
Clinical Investigation

Abstract

Objective

This study was designed to compare the clinical effectiveness of intraluminal radioactive stent loaded with iodine-125 seeds implantation versus covered stent alone insertion in patients with malignant esophageal stricture.

Methods

We studied two groups of patients with malignant esophageal stricture. Group A comprised 28 patients (19 men and 9 women) who underwent intraluminal radioactive stent loaded with iodine-125 seeds implantation and were followed prospectively. Group B comprised 30 patients (18 men and 12 women) who had previously received covered stent alone insertion; these patients were evaluated retrospectively. There was no crossover between the two groups during follow-up. Informed consent was obtained from each patient, and our institutional review board approved the study. The dysphagia score, overall survival rates, complication rates, and reintervention rates were compared in the two groups.

Results

There were no significant differences between the two groups in terms of baseline characteristics. Stent placement was technically successful and well tolerated in all patients. The dysphagia score was improved in both groups after stent placement. The median survival was significantly longer in group A than in group B: 11 versus 4.9 months, respectively (P < 0.001). The complications of chest pain, esophageal reflux, and stent migration was more frequent in group B, but this difference did not reach statistical significance. There was no statistical difference in reintervention between two groups.

Conclusions

Intraluminal radioactive stent loaded with iodine-125 seeds implantation was a feasible and practical management in treating malignant esophageal stricture and was superior to covered stent alone insertion, as measured by survival.

Keywords

Intraluminal radioactive stent Covered stent alone Malignant esophageal stricture Implantation 

Notes

Acknowledgments

Supported by grant from the National Scientific Foundation Committee of China (Grant No. 30870585/81071244) and from the Shanghai Luwan District Scientific Foundation (Grant No. LKW08001).

Conflicts of interest

None.

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Copyright information

© Springer Science+Business Media, LLC and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE) 2011

Authors and Affiliations

  • Wang Zhongmin
    • 1
    • 2
  • Huang Xunbo
    • 3
  • Cao Jun
    • 4
  • Huang Gang
    • 5
  • Chen Kemin
    • 6
  • Liu Yu
    • 6
  • Liu Fenju
    • 7
    Email author
  1. 1.School of Radiation Medicine and Public HealthSoochow UniversitySuzhouChina
  2. 2.Department of RadiologyShanghai Ruijin Hospital Luwan BranchShanghaiChina
  3. 3.Department of General SurgeryShanghai Ruijin Hospital Luwan BranchShanghaiChina
  4. 4.Department of Interventional OncologyShanghai Dahua HospitalShanghaiChina
  5. 5.Nuclear Medicine, School of MedicineShanghai Jiao Tong UniversityShanghaiChina
  6. 6.Department of RadiologyShanghai Ruijin HospitalShanghaiChina
  7. 7.School of Radiation Medicine and Public HealthSoochow UniversitySuzhouChina

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