CardioVascular and Interventional Radiology

, Volume 34, Issue 2, pp 419–423

High Intensity Focused Ultrasound Ablation of Pancreatic Neuroendocrine Tumours: Report of Two Cases

  • Gianluigi Orgera
  • Miltiadis Krokidis
  • Lorenzo Monfardini
  • Guido Bonomo
  • Paolo Della Vigna
  • Nicola Fazio
  • Franco Orsi
Case Report


We describe the use of ultrasound-guided high-intensity focused ultrasound (HIFU) for ablation of two pancreatic neuroendocrine tumours (NETs; insulinomas) in two inoperable young female patients. Both suffered from episodes of severe nightly hypoglycemia that was not efficiently controlled by medical treatment. After HIFU ablation, local disease control and symptom relief were achieved without postinterventional complications. The patients remained free of symptoms during 9-month follow-up. The lesions appeared to be decreased in volume, and there was decreased enhancing pattern in the multidetector computed tomography control (MDCT). HIFU is likely to be a valid alternative for symptoms control in patients with pancreatic NETs. However, currently the procedure should be reserved for inoperable patients for whom symptoms cannot be controlled by medical therapy.


Interventional Radiology Interventional Oncology 


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Copyright information

© Springer Science+Business Media, LLC and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE) 2010

Authors and Affiliations

  • Gianluigi Orgera
    • 1
  • Miltiadis Krokidis
    • 2
  • Lorenzo Monfardini
    • 1
  • Guido Bonomo
    • 1
  • Paolo Della Vigna
    • 1
  • Nicola Fazio
    • 3
  • Franco Orsi
    • 1
  1. 1.Unit of Interventional RadiologyEuropean Institute of OncologyMilanItaly
  2. 2.Department of RadiologySt. Thomas` HospitalLondonUK
  3. 3.Division of Medical OncologyEuropean Institute of OncologyMilanItaly

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