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CardioVascular and Interventional Radiology

, Volume 33, Issue 5, pp 1009–1015 | Cite as

Ischemic Effects of Transcatheter Arterial Embolization with N-Butyl Cyanoacrylate-Lipiodol on the Colon in a Swine Model

  • Akira Ikoma
  • Nobuyuki Kawai
  • Morio SatoEmail author
  • Tetsuo Sonomura
  • Hiroki Minamiguchi
  • Motoki Nakai
  • Isao Takasaka
  • Kouhei Nakata
  • Shinya Sahara
  • Naohisa Sawa
  • Shintaro Shirai
  • Ichiro Mori
Laboratory Investigation

Abstract

This study was designed to assess the safety of transcatheter arterial embolization (TAE) with n-butyl cyanoacrylate-lipiodol (NBCA-Lp) for the large bowel and to investigate the vital response to NBCA-Lp in a swine model. In nine swine, nine arteries nourishing the colon were embolized with NBCA-Lp (1 ml of NBCA mixed with 4 ml of lipiodol): sigmoid-rectal branch artery in six swine, right colic branch artery in two, and middle colic branch artery in one. The amount of NBCA-Lp was 0.1–0.4 ml. Sacrifice was conducted 3 days after TAE to identify histological infarction. Classification was conducted retrospectively: group A, vasa recta without NBCA-Lp embolization despite TAE; group B, three or fewer vasa recta with NBCA-Lp embolization; and group C, five or more vasa recta with NBCA-Lp embolization. In one swine in group A, no necrotic focus was observed. In group B, three of four swine experienced no ischemic damage. The remaining one swine experienced necrosis of mucosal and submucosal layers in one-fourth of the circumference. In group C, all four swine with marginal artery and five vasa recta or more embolized experienced total necrosis of mucosa, submucosa, and smooth muscle layers of the whole colonic circumference. Significant difference on the extent of ischemic damage was observed between groups B and C (P < 0.05). Microscopically, NBCA-Lp induced acute vasculitis. Embolization of three or fewer vasa recta with NBCA-Lp induced no ischemic damage or limited necrosis, whereas embolization of five or more vasa recta with NBCA-Lp induced extensive necrosis.

Keywords

Transcatheter arterial embolization N-butyl cyanoacrylate Lipiodol Colon 

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Copyright information

© Springer Science+Business Media, LLC and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE) 2010

Authors and Affiliations

  • Akira Ikoma
    • 1
  • Nobuyuki Kawai
    • 1
  • Morio Sato
    • 1
    Email author
  • Tetsuo Sonomura
    • 1
  • Hiroki Minamiguchi
    • 1
  • Motoki Nakai
    • 1
  • Isao Takasaka
    • 1
  • Kouhei Nakata
    • 1
  • Shinya Sahara
    • 1
  • Naohisa Sawa
    • 1
  • Shintaro Shirai
    • 1
  • Ichiro Mori
    • 2
  1. 1.Department of RadiologyWakayama Medical UniversityWakayama-shi, WakayamaJapan
  2. 2.Second Department of PathologyWakayama Medical UniversityWakayama-shi, WakayamaJapan

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