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CardioVascular and Interventional Radiology

, Volume 33, Issue 6, pp 1168–1179 | Cite as

Main Bile Duct Stricture Occurring After Transcatheter Arterial Chemoembolization for Hepatocellular Carcinoma

  • Shiro MiyayamaEmail author
  • Masashi Yamashiro
  • Miho Okuda
  • Yuichi Yoshie
  • Yoshiko Nakashima
  • Hiroshi Ikeno
  • Nobuaki Orito
  • Kazuo Notsumata
  • Hiroyuki Watanabe
  • Daisyu Toya
  • Nobuyoshi Tanaka
  • Osamu Matsui
Clinical Investigation

Abstract

The purpose of this study was to evaluate the clinical course of main bile duct stricture at the hepatic hilum after transcatheter arterial chemoembolization (TACE) for hepatocellular carcinoma (HCC). Among 446 consecutive patients with HCC treated by TACE, main bile duct stricture developed in 18 (4.0%). All imaging and laboratory data, treatment course, and outcomes were retrospectively analyzed. All patients had 1 to 2 tumors measuring 10 to 100 mm in diameter (mean ± SD 24.5 ± 5.4 mm) near the hepatic hilum fed by the caudate arterial branch (A1) and/or medial segmental artery (A4) of the liver. During the TACE procedure that caused bile duct injury, A1 was embolized in 8, A4 was embolized in 5, and both were embolized in 5 patients. Nine patients (50.0%) had a history of TACE in either A1 or A4. Iodized oil accumulation in the bile duct wall was seen in all patients on computed tomography obtained 1 week later. Bile duct dilatation caused by main bile duct stricture developed in both lobes (n = 9), in the right lobe (n = 3), in the left lobe (n = 4), in segment (S) 2 (n = 1), and in S3 (n = 1). Serum levels of alkaline phosphatase and γ-glutamyltranspeptidase increased in 13 patients. Biloma requiring drainage developed in 2 patients; jaundice developed in 4 patients; and metallic stents were placed in 3 patients. Complications after additional TACE sessions, including biloma (n = 3) and/or jaundice (n = 5), occurred in 7 patients and were treated by additional intervention, including metallic stent placement in 2 patients. After initial TACE of A1 and/or A4, 8 patients (44.4%), including 5 with uncontrollable jaundice or cholangitis, died at 37.9 ± 34.9 months after TACE, and 10 (55.6%) have survived for 38.4 ± 37.9 months. Selective TACE of A1 and/or A4 carries a risk of main bile duct stricture at the hepatic hilum. Biloma and jaundice are serious complications associated with bile duct strictures.

Keywords

Hepatocellular carcinoma Transcatheter arterial chemoembolization Bile duct stricture Jaundice Biloma Metallic stent placement 

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Copyright information

© Springer Science+Business Media, LLC and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE) 2010

Authors and Affiliations

  • Shiro Miyayama
    • 1
    Email author
  • Masashi Yamashiro
    • 1
  • Miho Okuda
    • 1
  • Yuichi Yoshie
    • 1
  • Yoshiko Nakashima
    • 1
  • Hiroshi Ikeno
    • 1
  • Nobuaki Orito
    • 1
  • Kazuo Notsumata
    • 2
  • Hiroyuki Watanabe
    • 2
  • Daisyu Toya
    • 2
  • Nobuyoshi Tanaka
    • 2
  • Osamu Matsui
    • 3
  1. 1.Department of Diagnostic RadiologyFukuiken Saiseikai HospitalFukuiJapan
  2. 2.Department of Internal MedicineFukuiken Saiseikai HospitalFukuiJapan
  3. 3.Department of RadiologyKanazawa University Graduate School of Medical ScienceKanazawaJapan

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