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CardioVascular and Interventional Radiology

, Volume 33, Issue 4, pp 828–834 | Cite as

CT Fluoroscopy-Guided Lung Biopsy with Novel Steerable Biopsy Canula: Ex-Vivo Evaluation in Ventilated Porcine Lung Explants

  • Philipp J. SchaeferEmail author
  • Michael Fabel
  • Hendrik Bolte
  • Fritz K. W. Schaefer
  • Thomas Jahnke
  • Martin Heller
  • Johannes Lammer
  • Juergen Biederer
Laboratory Investigation
  • 127 Downloads

Abstract

The purpose was to evaluate ex-vivo a prototype of a novel biopsy canula under CT fluoroscopy-guidance in ventilated porcine lung explants in respiratory motion simulations. Using an established chest phantom for porcine lung explants, n = 24 artificial lesions consisting of a fat-wax-Lipiodol mixture (approx. 70HU) were placed adjacent to sensible structures such as aorta, pericardium, diaphragm, bronchus and pulmonary artery. A piston pump connected to a reservoir beneath a flexible silicone reconstruction of a diaphragm simulated respiratory motion by rhythmic inflation and deflation of 1.5 L water. As biopsy device an 18-gauge prototype biopsy canula with a lancet-like, helically bended cutting edge was used. The artificial lesions were punctured under CT fluoroscopy-guidance (SOMATOM Sensation 64, Siemens, Erlangen, Germany; 30mAs/120 kV/5 mm slice thickness) implementing a dedicated protocol for CT fluoroscopy-guided lung biopsy. The mean-diameter of the artificial lesions was 8.3 ± 2.6 mm, and the mean-distance of the phantom wall to the lesions was 54.1 ± 13.5 mm. The mean-displacement of the lesions by respiratory motion was 14.1 ± 4.0 mm. The mean-duration of CT fluoroscopy was 9.6 ± 5.1 s. On a 4-point scale (1 = central; 2 = peripheral; 3 = marginal; 4 = off target), the mean-targeted precision was 1.9 ± 0.9. No misplacement of the biopsy canula affecting adjacent structures could be detected. The novel steerable biopsy canula proved to be efficient in the ex-vivo set-up. The chest phantom enabling respiratory motion and the steerable biopsy canula offer a feasible ex-vivo system for evaluating and training CT fluoroscopy-guided lung biopsy adapted to respiratory motion.

Keywords

CT fluoroscopy Lung biopsy Biopsy canula Chest phantom Experimental study 

Notes

Acknowledgements

The work was supported by the CIRSE Fellowship Education Grant. The authors would like to thank Beata Hoffmann, PhD, and Gerard Morvan for their excellent technical support during the study.

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Copyright information

© Springer Science+Business Media, LLC and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE) 2009

Authors and Affiliations

  • Philipp J. Schaefer
    • 1
    Email author
  • Michael Fabel
    • 1
  • Hendrik Bolte
    • 1
  • Fritz K. W. Schaefer
    • 1
  • Thomas Jahnke
    • 1
  • Martin Heller
    • 1
  • Johannes Lammer
    • 2
  • Juergen Biederer
    • 1
  1. 1.Department of Diagnostic RadiologyUniversity Hospital Schleswig-Holstein Campus KielKielGermany
  2. 2.Department of Radiology, Division of Cardiovascular and Interventional RadiologyMedical University of ViennaViennaAustria

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