CardioVascular and Interventional Radiology

, Volume 33, Issue 2, pp 383–388 | Cite as

Transient Encephalopathy from Angiographic Contrast: A Rare Complication in Neurointerventional Procedures

  • Leopoldo Guimaraens
  • Elio Vivas
  • Andrés Fonnegra
  • Teresa Sola
  • Lluis Soler
  • Ernest Balaguer
  • Jaime Medrano
  • Carlo Gandolfo
  • Alfredo Casasco
Case Report


Neurotoxicity from contrast media used in angiography is a rare complication from these procedures. The infrequency with which it is encountered makes it a diagnostic challenge. We present the case of a 51-year-old male who, 30 min after successful angiography for treatment of a right carotid-ophthalmic fusiform aneurysm with a stent, developed psychomotor agitation, disorientation, and progressive left faciobrachial hemiparesis (4/5). An emergency nonenhanced CT showed marked cortical enhancement and edema in the right cerebral hemisphere. Cortical enhancement is thought to be secondary to contrast extravasation due to disruption of the blood–brain barrier. Angiography was performed immediately, without any pathologic findings. After this procedure there was an increase in the left faciobrachial hemiparesis (3/5), right gaze deviation, Gerstmann syndrome, and left anosognosia and left homonymous hemianopsia. Endovenous dexamethasone and mannitol were initiated. Twenty-four hours later an MRI showed no signs of acute infarct, just gyriform signal increase in the right cerebral hemisphere on FLAIR and a decrease in the edema observed before. The patient had progressive improvement of his neurological deficit. A control MRI done 5 days later was normal. The patient recovered completely and was discharged. This rare entity should be kept in mind but diagnosed only when all other causes have been ruled out, because more important and frequent causes, such as acute infarct, must be excluded promptly.


Contrast Neurotoxicity Blood–brain barrier Cortical edema Posterior reversible encephalopathy syndrome 


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Copyright information

© Springer Science+Business Media, LLC and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE) 2009

Authors and Affiliations

  • Leopoldo Guimaraens
    • 1
  • Elio Vivas
    • 1
  • Andrés Fonnegra
    • 1
  • Teresa Sola
    • 1
  • Lluis Soler
    • 2
  • Ernest Balaguer
    • 2
  • Jaime Medrano
    • 1
  • Carlo Gandolfo
    • 1
  • Alfredo Casasco
    • 3
  1. 1.Therapeutic and Interventional Angiography ServiceHospital General de CatalunyaSant Cugat del Vallès, BarcelonaSpain
  2. 2.Neurology ServiceHospital General de CatalunyaSant Cugat del Vallès, BarcelonaSpain
  3. 3.Clinica Nuestra Señora del RosarioMadridSpain

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