CardioVascular and Interventional Radiology

, Volume 31, Issue 6, pp 1184–1192 | Cite as

Reduction of Late In-Stent Stenosis in a Porcine Coronary Artery Model by Cobalt Chromium Stents with a Nanocoat of Polyphosphazene (Polyzene-F)

  • Ulrike Stampfl
  • Christof-Matthias Sommer
  • Heidi Thierjung
  • Sibylle Stampfl
  • Ruben Lopez-Benitez
  • Boris Radeleff
  • Irina Berger
  • Goetz M. Richter
Laboratory Investigation
First Online:
Received:
Revised:
Accepted:

Abstract

The purpose of this study was to investigate the potential of nanoscale coating with the highly biocompatible polymer Polyzene-F (PZF), in combination with cobalt chromium and stainless steel stents, to reduce in-stent stenosis, thrombogenicity, and vessel wall injury and inflammation. One bare cobalt chromium, PZF-nanocoated stainless steel or PZF-nanocoated cobalt chromium stent was implanted in right coronary artery of 30 mini-pigs (4- or 12-week follow-up). Primary study end points were in-stent stenosis and thrombogenicity. Secondary study end points were vessel wall injury and inflammation as evaluated by microscopy and a new immunoreactivity score applying C-reactive protein (CRP), tumor-necrosis factor alpha (TNFα), and TGFβ. At 12 weeks, angiography showed a significantly lower average loss in lumen diameter (2.1% ± 3.05%) in PZF-nanocoated cobalt chromium stents compared with stents in the other groups (9.73% ± 4.93% for bare cobalt chromium stents and 9.71% ± 7% for PZF-nanocoated stainless steel stents; p = 0.04), which was confirmed at microscopy (neointima 40.7 ± 16 μm in PZF-nanocoated cobalt chromium stents, 74.7 ± 57.6 μm in bare cobalt chromium stents, and 141.5 ± 109 μm in PZF-nanocoated stainless steel stents; p = 0.04). Injury and inflammation scores were low in all stents and were without significant differences. PZF-nanocoated cobalt chromium stents provided the highest efficacy in reducing in-stent stenosis at long-term follow-up. The PZF nanocoat proved to be biocompatible with respect to thromboresistance and inflammation. Our data suggest that its combination with cobalt chromium stents might provide an interesting passive stent platform.

Keywords

In-stent stenosis Cobalt chromium Polymer coating Polyzene®-F Inflammation 
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Notes

Acknowledgments

This study was sponsored in part by CeloNova BioSciences, Newnan, GA. Stampfl, R. Lopez-Benitez, and G. M. Richter have sponsored research agreements with CeloNova BioSciences. G. M. Richter has served as consultant to CeloNova BioSciences.

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Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Ulrike Stampfl
    • 1
  • Christof-Matthias Sommer
    • 1
  • Heidi Thierjung
    • 1
  • Sibylle Stampfl
    • 1
  • Ruben Lopez-Benitez
    • 1
  • Boris Radeleff
    • 1
  • Irina Berger
    • 2
  • Goetz M. Richter
    • 1
  1. 1.Department of RadiologyUniversity of HeidelbergHeidelbergGermany
  2. 2.Department of PathologyUniversity of HeidelbergHeidelbergGermany

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