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CardioVascular and Interventional Radiology

, Volume 30, Issue 2, pp 196–200 | Cite as

Onyx, a New Liquid Embolic Material for Peripheral Interventions: Preliminary Experience in Aneurysm, Pseudoaneurysm, and Pulmonary Arteriovenous Malformation Embolization

  • Ritva L. VanninenEmail author
  • I. Manninen
CLINICAL INVESTIGATION

Abstract

Purpose

To describe our preliminary experience with a new liquid embolization agent, Onyx, in peripheral interventions.

Methods and results

We successfully treated two peripheral aneurysms (one in an internal iliac artery, one in a thoracic collateral artery of an aortic coarctation), two peripheral pseudoaneurysms (one in a lumbar artery, one in a renal artery), and one pulmonary arteriovenous malformation.

Conclusion

Onyx is a promising alternative embolic material for peripheral interventions. It can be combined with coils in selected cases, and balloon catheters can be effectively used during slow injection of embolic material to control flow and protect the aneurysm neck.

Keywords

Embolization Liquid embolization Onyx Peripheral intervention 

References

  1. 1.
    Brothers MF, Kaufmann JC, Fox AJ, et al (1989) n-Butyl 2-cyanoacrylate—substitute for IBCA in interventional neuroradiology: Histopathologic and polymerization time studies. AJNR Am J Neuroradiol 10:777–786PubMedGoogle Scholar
  2. 2.
    Smith MD, Russell EJ, Levy R, et al (1990) Transcatheter obliteration of a cerebellar arteriovenous fistula with platinum coils. AJNR Am J Neuroradiol 11:1199–1202PubMedGoogle Scholar
  3. 3.
    Germano IM, Davis RL, Wilson CB, et al (1992) Histopathological follow-up study of 66 cerebral arteriovenous malformations after therapeutic embolization with polyvinyl alcohol. J Neurosurg 76:607–614PubMedGoogle Scholar
  4. 4.
    Wallace RC, Flom RA, Khayata MH, et al (1995) The safety and effectiveness of brain arteriovenous malformation embolization using acrylic and particles: The experiences of a single institution. Neurosurgery 37:606–615; discussion 615–618PubMedGoogle Scholar
  5. 5.
    Wright KC, Greff RJ, Price RE (1999) Experimental evaluation of cellulose acetate NF and ethylene-vinyl alcohol copolymer for selective arterial embolization. J Vasc Interv Radiol 10:1207–1218PubMedCrossRefGoogle Scholar
  6. 6.
    Molyneux AJ, Coley SC (2000) Embolization of spinal cord arteriovenous malformations with an ethylene vinyl alcohol copolymer dissolved in dimethyl sulfoxide (Onyx liquid embolic system). Report of two cases. J Neurosurg 93:304–308Google Scholar
  7. 7.
    Jahan R, Murayama Y, Gobin YP, et al (2001) Embolization of arteriovenous malformations with Onyx: Clinicopathological experience in 23 patients. Neurosurgery 48:984–995; discussion 995–997PubMedCrossRefGoogle Scholar
  8. 8.
    Mawad ME, Cekirge S, Ciceri E, et al (2002) Endovascular treatment of giant and large intracranial aneurysms by using a combination of stent placement and liquid polymer injection. J Neurosurg 96:474–482PubMedCrossRefGoogle Scholar
  9. 9.
    Cekirge HS, Saatci I, Ozturk MH, et al (2006) Late angiographic and clinical follow-up results of 100 consecutive aneurysms treated with Onyx reconstruction: Largest single-center experience. Neuroradiology 48:113–126PubMedCrossRefGoogle Scholar
  10. 10.
    Castaneda F, Goodwin SC, Swischuk JL, et al (2002) Treatment of pelvic arteriovenous malformations with ethylene vinyl alcohol copolymer (Onyx). J Vasc Interv Radiol 13:513–516PubMedGoogle Scholar
  11. 11.
    Martin ML, Dolmatch BL, Fry PD, et al (2001) Treatment of type II endoleaks with Onyx. J Vasc Interv Radiol 12:629–632PubMedGoogle Scholar
  12. 12.
    Vinters HV, Galil KA, Lundie MJ, et al (1985) The histotoxicity of cyanoacrylates. A selective review. Neuroradiology 27:279–291PubMedCrossRefGoogle Scholar
  13. 13.
    Duffner F, Ritz R, Bornemann A, et al (2002) Combined therapy of cerebral arteriovenous malformations: Histological differences between a non-adhesive liquid embolic agent and n-butyl 2-cyanoacrylate (NBCA). Clin Neuropathol 21:13–17PubMedGoogle Scholar
  14. 14.
    Murayama Y, Vinuela F, Ulhoa A, et al (1998) Nonadhesive liquid embolic agent for cerebral arteriovenous malformations: Preliminary histopathological studies in swine rete mirabile. Neurosurgery 43:1164–1175PubMedCrossRefGoogle Scholar
  15. 15.
    Komemushi A, Tanigawa N, Okuda Y, et al (2002) A new liquid embolic material for liver tumors. Acta Radiol 43:186–191PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media, Inc. 2007

Authors and Affiliations

  1. 1.Department of Clinical RadiologyKuopio University HospitalKuopioFinland

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