CardioVascular and Interventional Radiology

, Volume 30, Issue 3, pp 392–397 | Cite as

Evaluation of Extrahepatic Perfusion of Anticancer Drugs in the Right Gastric Arterial Region on Fused Images Using Combined CT/SPECT: Is Extrahepatic Perfusion Predictive of Gastric Toxicity?

  • Osamu Ikeda
  • Yoshitaka Tamura
  • Yutaka Nakasone
  • Shinya Shiraishi
  • Kouichi Kawanaka
  • Seiji Tomiguchi
  • Shouji Morishita
  • Hiroshi Takamori
  • Akira Chikamoto
  • Keiichirou Kanemitsu
  • Yasuyuki Yamashita
Article
First Online:

Abstract

Background

Hepatic arterial infusion (HAI) chemotherapy is effective for treating primary and metastatic carcinomas of the liver. Since hepatic arteries also supply the stomach and duodenum, HAI may result in unwanted infusion into the upper gastrointestinal tract and consequent gastric toxicity. Using fused images obtained with a combined SPECT/CT system, we assessed extrahepatic perfusion (EHP) and its correlation with gastrointestinal toxicity in patients receiving HAI.

Methods

We studied 41 patients with primary or metastatic carcinoma of the liver who received HAI chemotherapy consisting of 5-fluorouracil and cisplatin. All underwent abdominal SPECT using a 99mTc-MAA (185 MBq) instrument and an injection rate of 0.1 ml/min, identical to the chemotherapy infusion rate. Delivery was through an implantable port. We analyzed the distribution of the anticancer agent on fused images and the relationship between EHP of the right gastric arterial region and gastric toxicity. All patients underwent esophagogastroduodenoscopy (EGDS).

Results

Of the 41 patients, 11 (27%) manifested enhancement of the duodenal and gastric pyloric region on fused images. EGDS at the time of reservoir placement detected gastric ulcers in 10 of these patients.

Conclusion

Fusion imaging with combined SPECT/CT reflects the actual distribution of the infused anticancer agents. The detection of EHP on fused images is predictive of the direct gastric toxicity from anticancer agents in patients undergoing HAI.

Keywords

Complication Interventional Radiology 
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Copyright information

© Springer Science+Business Media, Inc. 2007

Authors and Affiliations

  • Osamu Ikeda
    • 1
  • Yoshitaka Tamura
    • 1
  • Yutaka Nakasone
    • 1
  • Shinya Shiraishi
    • 1
  • Kouichi Kawanaka
    • 1
  • Seiji Tomiguchi
    • 1
  • Shouji Morishita
    • 1
  • Hiroshi Takamori
    • 2
  • Akira Chikamoto
    • 2
  • Keiichirou Kanemitsu
    • 2
  • Yasuyuki Yamashita
    • 1
  1. 1.Department of Diagnostic RadiologyKumamoto University Graduate School of Medical and Pharmaceutical SciencesKumamotoJapan
  2. 2.Department of Gastroenterological SurgeryKumamoto University Graduate School of Medical and Pharmaceutical SciencesKumamotoJapan

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